A271
Anti-α2A Adrenergic Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Autenticati per visualizzare i prezzi organizzativi e contrattuali.
Scegli un formato
Informazioni su questo articolo
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), WB
Citations:
6
Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutartiServizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutartibiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~45 kDa
species reactivity
rat, human, mouse, pig
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1000, western blot: 1:500
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ADRA2A(150)
mouse ... Adra2a(11551)
rat ... Adra2a(25083)
General description
Adrenergic receptors (ARs) belong to the 7-transmembrane domain G protein-coupled receptor superfamily that binds to the endogenous catecholamines, epinephrine and norepinephrine. α2AR subtypes block adenylyl cyclase, suppress voltage-sensitive Ca2+ channels, and stimulate receptor dependent K+ channels. All of the α2AR subtypes inhibit adenylyl cyclase through coupling to members of the Gi/Go class of G proteins. They are an important component of the neural circuitry and modulate cardiovascular physiology. The physiological function of the α2ARs in the kidney is to regulate Na+/H+ exchange.
Anti-α2A adrenergic receptor detects rat and mouse α2A adrenergic receptors by immunoblotting and immunohistochemistry. In immunoblotting, the antibody detects an approx. 45kDa band representing α2A receptors in tissues expressing this receptor subtype, although some non-specific bands have also been observed in certain cases.
Anti-α2A adrenergic receptor detects rat and mouse α2A adrenergic receptors by immunoblotting and immunohistochemistry. In immunoblotting, the antibody detects an approx. 45kDa band representing α2A receptors in tissues expressing this receptor subtype, although some non-specific bands have also been observed in certain cases.
Immunogen
synthetic peptide derived from amino acids 218-235 of human, mouse, rat, and pig α2A adrenergic receptor. The immunogen sequence is found within the third intracellular loop of the α2A adrenergic receptor subtype.
Application
Rabbit anti-α2A adrenergic receptor antibody can be used for western blot (1:500) and immunohistochemistry (1:1000) applications.
Physical form
Solution in phosphate buffered saline, containing 1 mg/ml BSA and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Non trovi il prodotto giusto?
Prova il nostro Motore di ricerca dei prodotti.
Classe di stoccaggio
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Olena Fedotkina et al.
Frontiers in neuroscience, 16, 858049-858049 (2022-05-24)
Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are not known. In the present study, we aimed to investigate the
Elvira Ganic et al.
Cell reports, 14(8), 1991-2002 (2016-02-26)
Monoamine and acetylcholine neurotransmitters from the autonomic nervous system (ANS) regulate insulin secretion in pancreatic islets. The molecular mechanisms controlling neurotransmitter signaling in islet β cells and their impact on diabetes development are only partially understood. Using a glucose-intolerant, MafA-deficient
Wenli Mi et al.
Anesthesia and analgesia, 125(3), 1032-1041 (2017-05-26)
Combination drug therapy is commonly used to treat chronic pain conditions such as neuropathic pain, and antidepressant is often used together with opioid analgesics. While rewarding is an intrinsic property of opioid analgesics, it is unknown whether the use of
Shigekazu Sugino et al.
Genes, brain, and behavior, e12759-e12759 (2021-06-12)
The genetic mechanisms of postoperative nausea and vomiting (PONV) and the involvement of the catecholamine system in the brain have not been elucidated. Eating kaolin clay as a type of pica has been examined as an alternative behavior to emesis.
Dong Ji et al.
Experimental and therapeutic medicine, 14(5), 4910-4918 (2017-12-05)
As a therapeutic target for neuropathic pain, the anti-nociceptive effects of α 2-adrenoceptors (α2AR) have attracted attention. Dexmedetomidine (DEX), a potent and highly selective α2AR agonist, has exhibited significant analgesic effects in neuropathic pain, but the underlying mechanism has remained
Contenuto correlato
Instructions
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| A271-100UL | 04061837829734 |
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica