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A1755

Sigma-Aldrich

Aminophylline dihydrochloride hyderate

≥98%, powder

Sinonimo/i:

(Theophylline)2 · Ethylenediamine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1), Theophylline hemiethylenediamine complex

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CHF 58.60
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CHF 103.00

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25 G
CHF 58.60
100 G
CHF 103.00

About This Item

Formula empirica (notazione di Hill):
C7H8N4O2 · 0.5C2H8N2
Numero CAS:
317-34-0
Peso molecolare:
210.21
Numero CE:
206-264-5
Numero MDL:
MFCD00013221
Codice UNSPSC:
41106305
ID PubChem:
24277691
NACRES:
NA.77

CHF 58.60

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Saggio

≥98%

Stato

powder

Colore

white to off-white

Solubilità

H2O: 50 mg/mL (solutions should be freshly prepared.)
alcohol: insoluble

Temperatura di conservazione

−20°C

Stringa SMILE

NCCN.CN1C(=O)N(C)c2nc[nH]c2C1=O.CN3C(=O)N(C)c4nc[nH]c4C3=O

InChI

1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2
FQPFAHBPWDRTLU-UHFFFAOYSA-N

Informazioni sul gene

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

Applicazioni

Aminophylline has been used:
  • as a positive control in the selective inhibitor of nuclear export, KPT-350 zebrafish dosing experiments[1]
  • as a positive control for the determination of the spasmolytic activity of C. aeruginosa extracts[2]
  • as a phosphodiesterase (PDE) inhibitor in inhibitor studies to quantify its potency to inhibit PDE4A1A and PDE3A enzyme in an assay[3]

Azioni biochim/fisiol

Aminophylline is a methylxanthine compound containing theophylline andethylenediamine in a ratio of 2:1. It acts as a bronchodilator and is used to treat chronic lung diseases like asthma, bronchitis, or emphysema.[4]
Non-selective phosphodiesterase (PDE) inhibitor. Antiepileptic drug

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKCT6059
MKCS2794
MKCS7148
MKCL4313
MKCJ3828

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K C Crisanti et al.
The American journal of physiology, 277(3 Pt 2), R829-R835 (1999-09-14)
In newborns and adults of a number of species, exposure to acute hypoxemia produces a "regulated" decrease in core temperature, the mechanism of which is unknown. The present experiments were carried out on chronically instrumented newborn (5-10 days of age;
Ram Manohar Basnet et al.
BMC pharmacology & toxicology, 18(1), 72-72 (2017-11-17)
Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline, doxofylline, etophylline, 3-isobutyl-1-methylxanthine (IBMX), pentoxifylline and theophylline. Microinjections of the
Saniyya Khan et al.
Journal of biomolecular structure & dynamics, 39(3), 970-976 (2020-01-30)
Aminophylline (Am) is a methylxanthine compound clinically applied for chronic lung diseases like asthma, bronchitis or emphysema. Chemically, it comprises theophylline and ethylenediamine in a ratio 2:1. For the widening of the therapeutic window of any class of drug or
Antiasthmatic effect of Curcuma aeruginosa extract on isolated organ of the trachea
Marliana E, et al.
F1000Research (2018)
Danieli Barino Salinas et al.
Pediatric research, 87(1), 137-145 (2019-07-26)
There is a need to prognosticate the severity of cystic fibrosis (CF) detected by newborn screening (NBS) by early assessment of CF transmembrane conductance regulator (CFTR) protein function. We introduce novel instrumentation and protocol for evaluating CFTR activity as reflected
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