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A1439

Pituitary adenylate cyclase activating polypeptide-38

Sinonimo/i:

PACAP-38

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Voi/SKUDisponibilitàPrezzo
0.1 mg
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CHF 317.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C203H331N63O53S
Numero CAS:
Peso molecolare:
4534.26
UNSPSC Code:
41106305
NACRES:
NA.32
MDL number:
Form:
powder

CHF 317.00


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form

powder

Quality Segment

composition

Peptide content, ~70%

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... ADCYAP1(116)

General description

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is mapped to human chromosome 18. 27-residue-amidated fragment (PACAP27) comprises another isoform. The PACAP38 is major isoform associated with mammals.

Application

Pituitary adenylate cyclase activating polypeptide-38 has been used to test its effect in stimulating the formation of cyclic AMP hypothalamus and cerebral cortex slices of chicken and to treat glioblastoma cells (U87MG) in cell migration assay to test its anti-invasive effects.

Biochem/physiol Actions

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a cardioprotectant and may help in treating radiation-induced heart disease (RIHD). It plays a protective role during oxidative stress in cardiomyocytes. PACAP38 has antioxidant, anti-apoptotic and anti-inflammatory property. It is implicated in the pathophysiology of migraine and cluster headache.
PACAP-38 is a neuropeptide that has substantial sequence homology to vasoactive intestinal peptide (VIP). It is reported to serve as a neuronal survival factor.

Other Notes

Lyophilized from 0.1% TFA in H2O

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Questo articolo
AB2265SAB4503084
description

-

description

from rabbit, purified by affinity chromatography

description

affinity isolated antibody

form

powder

form

-

form

buffered aqueous solution

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

composition

Peptide content, ~70%

composition

-

composition

-

Gene Information

human ... ADCYAP1(116)

Gene Information

human ... VIPR1(7433)

Gene Information

human ... VIPR1(7433)

UniProt accession no.

P18509

UniProt accession no.

P97751

UniProt accession no.

P32241


Classe di stoccaggio

11 - Combustible Solids

Che succede?

WGK 3

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

DPI (dispositivi di protezione individuale)

Eyeshields, Gloves, type N95 (US)



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Questions

  1. How can stock solutions for item A1439, Pituitary adenylate cyclase activating polypeptide-38, be reconstituted and stored?

    1 answer
    1. The solubility information can be found on the Specification sheet: Solubility (Solvent) Water or 1% Acetic Acid Solubility (Conc) 1.00 - 1.04 mg/ml. Stock solutions are stable for up to 3 months at -20°C.

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