BAPTA-AM is shipped at ambient temperature. The recommended storage temperature, once received, is -20 °C.
A1076
BAPTA-AM
≥95% (HPLC), powder, intracellular Ca²⁺ store chelator
Sinonimo/i:
1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)
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Cambia visualizzazione
| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 739.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C34H40N2O18
Numero CAS:
Peso molecolare:
764.68
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
7458534
Assay:
≥95% (HPLC)
Form:
powder
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
BAPTA-AM, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccccc1OCCOc2ccccc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O
InChI
1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChI key
YJIYWYAMZFVECX-UHFFFAOYSA-N
General description
BAPTA-AM inhibits free radical-mediated toxicity, enhances apoptosis in non-neuronal cells and protects neurons from ischemic damage. It regulates ion channels and blocks neuronal Ca2+-activated K+ channel currents. BAPTA-AM maintains intracellular Ca2+ homeostasis.
Application
BAPTA-AM has been used :
- to reduce the elevation of cleaved caspase-3
- to block cell death, inhibit ROS (reactive oxygen species) production and inhibit caspase-8 activation
- to exclude the effect of changes in intracellular Ca2+ ([Ca2+]i) concentration during seizure induction
- to eliminate the increase of [Ca2+]i induced by 6-hydroxydopamine (6-OHDA)
Biochem/physiol Actions
Selective chelator of intracellular Ca2+ stores.
Other Notes
Membrane-permeable form of BAPTA.
1 of 1
Questo articolo | |||
|---|---|---|---|
| form powder | form solid | form solid | form solid |
| assay ≥95% (HPLC) | assay ≥90% (TLC) | assay - | assay ≥90% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
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Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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What are the shipping and storage temperatures for BAPTA-AM, Product A1076?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the typical working concentration for BAPTA-AM, Product A1076?
1 answer-
The typical final working concentrations for cell loading is in the range of 1 to 10 micromolar. It is best to find literature references dealing with your application for more information on the amounts to use.
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How would you recommend that I store my BAPTA-AM, Product A1076, solution?
1 answer-
Stock solutions of 1-10 mM can be prepared in anhydrous DMSO, divided into single-use aliquots, and stored desiccated and frozen at -20°C.
Helpful?
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What is BAPTA-AM, Product A1076, and how is it used?
1 answer-
BAPTA-AM is a cell-permeant acetoxymethyl ester derivative of BAPTA (Product No. A4926), which is used as a chelator of intracellular Ca2+ stores. The acetoxymethyl ester derivative, which is an ester of the carboxylic acid groups in BAPTA, results in an uncharged molecule which allows it to penetrate cell membranes. Inside the cell, these groups are cleaved by nonspecific esterase activity resulting in the free acid form.
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In what solvents is BAPTA-AM, Product A1076, soluble?
1 answer-
BAPTA-AM is soluble in dimethyl sulfoxide (DMSO) at 25 mg/mL. It is also soluble in acetonitrile at 0.5 mg/mL. It is best to use anhydrous DMSO, since it is known that moisture uptake by the DMSO can adversely affect the quality of the BAPTA-AM.
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