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87787

Sigma-Aldrich

6-(4-Methoxyphenyl)-2-methyl-3,7-dihydroimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride

suitable for chemiluminescence, ≥98.0% (HPLC)

Sinonimo/i:

2-Methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride, Cypridina Luciferin methoxy-analogue, MCLA

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About This Item

Formula empirica (notazione di Hill):
C14H13N3O2 · HCl
Numero CAS:
128322-44-1
Peso molecolare:
291.73
Beilstein:
5838857
Numero MDL:
MFCD00144728
Codice UNSPSC:
12352200
ID PubChem:
57653269
NACRES:
NA.32

Descrizione

luminescence test: Emmax465 nm, 0.1 M Tris pH 8.5; after addition of H2O2 (Chemiluminescence: in 0.1 M Tris pH 8.5; after addition of H2O2)

Saggio

≥98.0% (HPLC)

Forma fisica

powder

Solubilità

DMSO: soluble
H2O: soluble

Compatibilità

suitable for chemiluminescence

Stringa SMILE

Cl[H].COc1ccc(cc1)C2=CN3C(=O)C(C)=NC3=CN2

InChI

1S/C14H13N3O2.ClH/c1-9-14(18)17-8-12(15-7-13(17)16-9)10-3-5-11(19-2)6-4-10;/h3-8,15H,1-2H3;1H
KGMPQNFFCUDXSO-UHFFFAOYSA-N

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Altre note

Generation of chemiluminescence by reaction with super oxide O2– or singlet oxygen. Used in research of leucocyte function.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Yasuhiro Kambayashi et al.
Journal of clinical biochemistry and nutrition, 41(1), 68-75 (2008-04-09)
We have proposed that diacylglycerol hydroperoxide-induced unregulated signal transduction causes oxidative stress-related diseases. In this study, we investigated which molecular species of diacylglycerol hydroperoxide activated human peripheral neutrophils. All diacylglycerol hydroperoxides, diacylglycerol hydroxides, and diacyglycerols tested in the present study
A Takahashi et al.
FEBS letters, 261(2), 369-372 (1990-02-26)
To investigate O2- generation in in situ lungs of rats treated with drugs to induce experimental acute respiratory distress syndrome, phorbol myristate acetate (PMA) or endotoxin were injected into rats, who had been continuously infused with 2(methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo[1,2-alpha]pyraz in-3-one (MCLA) and
Hagop Kojanian et al.
American journal of therapeutics, 23(6), e1456-e1463 (2014-05-08)
Statins have favorable effects on endothelial function partly because of their capacity to reduce oxidative stress. However, antioxidant vitamins, unlike statins, are not as cardioprotective, and this paradox has been explained by failure of vitamin antioxidants to ameliorate endoplasmic reticulum
Keiko Suzuki et al.
Antioxidants (Basel, Switzerland), 9(6) (2020-06-13)
Bisphosphonates (BPs) are classified into two groups, according to their side chain structures, as nitrogen-containing BPs (NBPs) and non-nitrogen-containing BPs (non-NBPs). In this study, we examined the effects of NBPs and non-NBPs on inflammatory responses, by quantifying the inflammatory mediators
Julia M Diaz et al.
Nature communications, 7, 13801-13801 (2016-12-08)
The reactive oxygen species superoxide (O2·-) is both beneficial and detrimental to life. Within corals, superoxide may contribute to pathogen resistance but also bleaching, the loss of essential algal symbionts. Yet, the role of superoxide in coral health and physiology
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