74675

Novobiocina

≥93% (HPLC)

• Sinonimo/i: Albamycin, Cathomycin, Novobiocin, Novobiocin, Monosodium Salt
• Formula empirica (notazione di Hill): C₃₁H₃₅N₂NaO₁₁
• Numero CAS: 1476-53-5
• Peso molecolare: 634.61
• UNSPSC Code: 51286504
• NACRES: NA.85
• EC Number: 216-023-6
• Beilstein/REAXYS Number: 3892910

Proprietà

• assay: ≥93% (HPLC)
• form: powder
• optical activity: [α]20/D −48±3°, c = 1% in ethanol
• color: white to faint beige
• solubility: H₂O: soluble
• antibiotic activity spectrum: Gram-positive bacteria
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: [Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C
• InChI: 1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
• InChI key: AXOUUAINTJNFRS-UHFFFAOYSA-N

Descrizione

General description

Chemical structure: coumarin-glycoside

Application

Per la produzione di DNA plasmidico a superelica positiva. Inibitore della DNA girasi batterica e della DNA topoisomerasi eucariotica. Inibitore della DNA polimerasi RNA-dipendente di retrovirus.

Novobiocin is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA. It is an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. It also is an inhibitor of retrovirus RNA-dependent DNA-polymerase.

Biochem/physiol Actions

Modalità d′azione: Impedisce la sintesi del DNA mediante l′inibizione dell′enzima topoisomerasi II.
Spettro antimicrobico: Batteri Gram-positivi.

Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitors of the ATPase reaction catalysed by GyrB . It is also a Hsp90 inhibitor . Antimicrobial spectrum: Gram-positive bacterial.

Packaging

1g, 5g

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Store under inert gas. Keep in a dry place.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H317,H319
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves