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55212

Phalloidin–Atto Rho6G

Name: Phalloidin–Atto Rho6G
Brand: SIGMA

suitable for fluorescence, ≥90% (HPCE)

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A voi/SKU	Disponibilità	Prezzo

Informazioni su questo articolo

NACRES:

NA.32

UNSPSC Code:

12352116

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Proprietà

Quality Segment

100

assay

≥90% (HPCE)

form

solid

mol wt

M_w 1396 g/mol

manufacturer/tradename

ATTO-TEC GmbH

fluorescence

λ_ex 535 nm; λ_em 560 nm in 0.1 M phosphate pH 7.0

suitability

suitable for fluorescence

storage temp.

−20°C

Descrizione

General description

Atto Rho6G is a novel fluorescent label that belongs to the class of Rhodamine dyes. It shows a strong absorption, extraordinary high fluorescence quantum yield, high thermal and photostability, and a very little triplet formation. Atto Rho6G is moderately hydrophilic.Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind F-actin in liver and muscle cells. As a result of binding phalloidin, actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin, and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10–8. Phalloidin differs from amanitin in rapidity of action; at high dose levels, death of mice or rats occurs within 1 or 2 hours.

Application

Fluorescent conjugates of phalloidin, rhodamine-phalloidin staining reagents, such as Phalloidin–Atto Rho6G are used to label actin filaments for histological applications. Some structural features of phalloidin are required for the binding to actin. However, the side chain of amino acid 7 (g-dihydroxyleucine) is accessible for chemical modifications without appreciable loss of affinity for actin.

Legal Information

This product is for Research use only. In case of intended commercialization, please contact the IP-holder (ATTO-TEC GmbH, Germany) for licensing.

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Questo articolo	18846	19083	79286
Sigma-Aldrich 55212 Phalloidin–Atto Rho6G	Sigma-Aldrich 18846 Atto 655 Phalloidin	Sigma-Aldrich 19083 Phalloidin–Atto 550	Sigma-Aldrich 79286 Phalloidin–Atto 700
suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence
fluorescence λ_ex 535 nm; λ_em 560 nm in 0.1 M phosphate pH 7.0	fluorescence λ_ex 663 nm; λ_em 684 nm in 0.1 M phosphate pH 7.0	fluorescence -	fluorescence λ_ex 700 nm; λ_em 719 nm in 0.1 M phosphate pH 7.0
form solid	form solid	form solid	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
assay ≥90% (HPCE)	assay ≥90.0% (sum of isomers, HPLC)	assay ≥90% (HPLC)	assay ≥90% (HPLC)

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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