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52442

Sigma-Aldrich

Monascin

≥97.0% (HPLC)

Sinonimo/i:

(3S,3aR,9aR)-3-Hexanoyl-9a-methyl-6-((E)-propenyl)-3a,4,8,9a-tetrahydro-3H-furo[3,2-g]isochromene-2,9-dione, (3S,3aR,9aR)-3a,4,8,9a-Tetrahydro-9a-methyl-3-(1-oxohexyl)-6-(1E)-1-propenyl-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione, Monascoflavin

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About This Item

Formula empirica (notazione di Hill):
C21H26O5
Numero CAS:
21516-68-7
Peso molecolare:
358.43
Beilstein:
51355
Numero MDL:
MFCD09260177
Codice UNSPSC:
12352200
ID PubChem:
329757837
NACRES:
NA.47

Saggio

≥97.0% (HPLC)

Stato

solid

applicazioni

metabolomics
vitamins, nutraceuticals, and natural products

Temperatura di conservazione

2-8°C

Stringa SMILE

CCCCCC(=O)[C@@H]1[C@H]2CC3=C(COC(\C=C\C)=C3)C(=O)[C@]2(C)OC1=O

InChI

1S/C21H26O5/c1-4-6-7-9-17(22)18-16-11-13-10-14(8-5-2)25-12-15(13)19(23)21(16,3)26-20(18)24/h5,8,10,16,18H,4,6-7,9,11-12H2,1-3H3/b8-5+/t16-,18+,21-/m1/s1
XXKNHBAFFJINCK-RVEJDSBJSA-N

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Categorie correlate

Descrizione generale

Monascin is one of the major yellow pigments found in red mold rice. It is structurally similar to ankaflavin.

Applicazioni

Monascin has been used to treat 4T1 breast cancer cells and to test its effects on tumor cells anoikis and growth prevention.

Azioni biochim/fisiol

Monascin (MS) exerts anti-diabetic and antioxidant properties and provides hyperglycemia control, tissue protection, and thermotolerance in diabetic rats and C. elegans, respectively. It also displays antitumor activity and inhibits Alzheimer′s disease-related tau protein aggregation. Monascin up-regulates high-density lipoprotein cholesterol (HDL-C) levels in hyperlipidemic hamsters model and possesses hypolipidemic properties. It may also possess hepatoprotective effects.
Monascin is one of the azaphilonoid pigments in extracts of Monascus pilosus-fermented rice (red-mold rice). It is a potent inhibitor of carcinogenesis measured against chemical or UV initiated, phorbol-promoted mouse skin tumors.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
BCBX3586
BCCG6950
BCBV5769
BCBT6470
BCBL8804V

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Qiuyu Lin et al.
Neuroreport, 31(9), 637-643 (2020-05-20)
Increasing evidence verified that oxidative stress and neuroinflammatory response exacerbates motor deficits and increases neuronal loss in several rodent models of Parkinson's disease. In the present study, we explore the neuroprotective effects of monascin in a rotenone-induced Parkinson's disease model
Yeu-Ching Shi et al.
Free radical biology & medicine, 52(1), 109-117 (2011-11-02)
Monascin is a major yellow compound from red mold dioscorea. We investigated monascin to test whether this compound acts as an antidiabetic and antioxidative stress agent in diabetic rats and Caenorhabditis elegans. The mechanisms by which monascin exerts its action
S L Gartner et al.
Thymus, 19(2), 117-126 (1992-03-01)
We examined the effect of various carbohydrates on the proliferative response of murine thymocytes to cytokines. The monosaccharide, D-mannose (4-10 mM), significantly inhibited thymocyte proliferation induced by recombinant interleukin-1 (rIL-1). Mannose also inhibited the proliferation response to native, human IL-1.
Malignant melanoma.
World journal of surgery, 16(2), 155-286 (1992-03-01)
[Symposium "Mechanisms of allergic inflammation". 2d Meeting of the Professional Society of the ADF: Immunologic mechanisms of inflammatory skin diseases. 21-23 February 1992, Freiburg i. Br].
W Czech
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 43(11), 743-744 (1992-11-01)
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