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49641

Alcohol Dehydrogenase, recombinant

≥500 U/mL

Sinonimo/i:

Alcohol:NADP+ oxidoreductase

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Informazioni su questo articolo

Numero CAS:
9028-12-0
UNSPSC Code:
12352204
NACRES:
NA.54
Numero CE:
1.1.1.2 (BRENDA, IUBMB)
MDL number:
MFCD00130451
Specific activity:
≥500 U/mL
Recombinant:
expressed in E. coli

recombinant

expressed in E. coli

form

liquid

specific activity

≥500 U/mL

technique(s)

cell based assay: suitable

color

light brownish-yellow to brown-green

suitability

suitable for molecular biology

application(s)

life science and biopharma

storage temp.

−20°C

General description

Research area: Neuroscience

Alcohol dehydrogenase has a homodimeric structure with a co-enzyme binding domain at the C-terminal and an N-terminal catalytic domain. The active site is located at the interdomain cleft. Binding of NAD+ in the active site causes conformational changes that create the binding site for the alcohol substrate.

Application

Alcohol dehydrogenase (ADH) has been used for the reversal of deficient 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay reduction in the disrupted schizophrenia 1 (DISC1-FL) and DB7 cell lysate.

Biochem/physiol Actions

Alcohol dehydrogenase catalyzes the oxidative conversion of alcohol into aldehyde. The metabolism of ethanol catalyzed by alcohol dehydrogenase (ADH) results in the generation of reactive oxygen species (ROS) and nitric oxide (NO) leading to oxidative damage to mitochondria and cellular proteins and is further associated with the onset of neuroinflammation and neurological disorders.

Other Notes

1 U corresponds to the amount of enzyme which reduces 1 μmol acetone per minute at pH 7.0 and 30°C (NADPH as cofactor)

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Questions

  1. From what organism is this alcohol dehydrogenase from

    1 answer

    1. This product is recombinant enzyme produced in e. coli. The original species information is not available.

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