10817
Apolipoprotein A-I from human plasma
≥90% (GE)
Sinonimo/i:
Apo A-1
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About This Item
Prodotti consigliati
Origine biologica
human plasma
Saggio
≥90% (GE)
Stato
lyophilized solid
PM
Mr ~28300
Solubilità
H2O: 1 mg/mL, clear, colorless
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... APOA1(335)
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Descrizione generale
Apolipoprotein A-I (apoA-I) is the chief protein component of high density lipoproteins (HDL) and a major determinant of HDL structure, composition, and stability. It is an exchangeable apolipoprotein and plays pivotal role in the metabolism of cholesterol. [1]
Applicazioni
Azioni biochim/fisiol
High-density lipoproteins are antiatherogenic and cardioprotective by facilitating reverse cholesterol transport (RCT). Some strategies for elevating apolipoprotein A-I levels are studied as therapies for atherosclerosis.
Nota sulla preparazione
lyophilized from 0.01 M ammonium hydrogen carbonate
Altre note
A principal protein component of high-density lipoproteins. Protein - lipid interactions[4]
Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Scott M Gordon et al.
Current opinion in endocrinology, diabetes, and obesity, 19(2), 109-114 (2012-01-27)
To review recently published advances in the development of apolipoprotein A-I (apoA-I) mimetic peptides as a potential treatment for cardiovascular diseases. Various apoA-I mimetic peptides are currently in development and these display potent cardioprotective features that can rival or even
Jens O Lagerstedt et al.
Biochimica et biophysica acta, 1821(3), 448-455 (2012-01-17)
Apolipoprotein A-I (apoA-I) is the major protein component of high density lipoproteins (HDL) and plays a central role in cholesterol metabolism. The lipid-free/lipid-poor form of apoA-I is the preferred substrate for the ATP-binding cassette transporter A1 (ABCA1). The interaction of
Weiling Wang et al.
Journal of lipid research, 51(9), 2560-2570 (2010-05-26)
The relationship between high-density lipoprotein and pulmonary function is unclear. To determine mechanistic relationships we investigated the effects of genetic deletion of apolipoprotein A-I (apoA-I) on plasma lipids, paraoxonase (PON1), pro-inflammatory HDL (p-HDL), vasodilatation, airway hyperresponsiveness and pulmonary oxidative stress
R.B. Gennis et al.
Annual Review of Biophysics and Biophysical Chemistry, 6, 195-195 (1977)
Ryan J Henderson et al.
Lipids in health and disease, 8, 27-27 (2009-07-25)
Haptoglobin is a plasma protein that scavenges haemoglobin during haemolysis. Phospholipid Transfer Protein (PLTP) transfers lipids from Low Density Lipoproteins (LDL) to High Density Lipoproteins (HDL). PLTP is involved in the pathogenesis of atherosclerosis which causes coronary artery disease, the
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