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T7645

Sigma-Aldrich

Tetracaine hydrochloride

Sigma Reference Standard

Sinonimo/i:

4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C15H24N2O2 · HCl
Numero CAS:
136-47-0
Peso molecolare:
300.82
Numero MDL:
MFCD00038912
Codice UNSPSC:
12352200
ID PubChem:
329826873

Grado

Sigma Reference Standard

Confezionamento

vial of 250 mg

Solubilità

alcohol: soluble in 40 parts solvent
chloroform: soluble in 30 parts of solvent
H2O: soluble 50 mg/mL, clear, colorless
acetone: insoluble
benzene: insoluble
diethyl ether: insoluble

Stringa SMILE

Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI

1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
PPWHTZKZQNXVAE-UHFFFAOYSA-N

Informazioni sul gene

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Applicazioni

Tetracaine hydrochloride has been used to analyze Ca2+ release from sarcoplasmic reticulum (SR) in neonatal ventricular cardiomyocytes (NVCMs). Tetracaine hydrochloride has also been used as a component of protease digestion buffers.
Topical ophthalmic anesthetic; used for spinal anesthesia

Azioni biochim/fisiol

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.

Confezionamento

Supplied in amber screw-cap vials

Nota sulla preparazione

Tetracaine hydrochloride dissolves in water at 50 mg/ml to yield a clear, colorless solution. It is also soluble in 40 parts alcohol and 30 parts chloroform. However, it is practically insoluble in ether benzene or acetone.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H319,H336

Classi di pericolo

Acute Tox. 3 Oral - Eye Irrit. 2 - STOT SE 3

Organi bersaglio

Central nervous system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
014F5965

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A M Knight et al.
European journal of immunology, 22(3), 879-882 (1992-03-01)
Recent reports have shown that both exogenous and endogenous mouse mammary tumor viruses (MMTV) can encode superantigens. Transfection and transgenic studies have identified the open reading frame (ORF) present in the 3' long terminal repeat (LTR) as encoding superantigen function.
Patrick Most et al.
Journal of cell science, 118(Pt 2), 421-431 (2005-01-18)
Calcium is a key regulator of cardiac function and is modulated through the Ca2+-sensor protein S100A1. S100 proteins are considered to exert both intracellular and extracellular functions on their target cells. Here we report the impact of an increased intracellular
Helen Giannakopoulos et al.
Journal of the American Dental Association (1939), 143(8), 872-880 (2012-08-03)
The authors evaluated the cardiovascular effects and pharmacokinetics of an intranasal 3 percent tetracaine/0.05 percent oxymetazoline spray developed to provide needle-free anesthesia of maxillary teeth. The authors administered to 12 participants a proposed maximum recommended dose (MRD) (18 milligrams tetracaine/0.3
Elisa Cinotti et al.
American journal of ophthalmology, 159(2), 324-333 (2014-12-03)
To evaluate whether the handheld in vivo reflectance confocal microscopy that has been recently developed for the study of skin tumors is suitable for the diagnosis of conjunctival tumors. Prospective study, observational case series. We prospectively evaluated the reflectance confocal
Patrick E McCleskey et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(1 Pt 1), 82-91 (2013-01-03)
Few published studies have analyzed serum lidocaine levels and individual patient characteristics affecting metabolism after application of compounded topical anesthetics. To measure serum lidocaine levels during and cutaneous side effects after standardized application of 23% lidocaine/7% tetracaine compounded anesthetic to
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