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Supelco

5′-Hydroxypiroxicam

VETRANAL®, analytical standard

Sinonimo/i:

4-Hydroxy-N-(5-hydroxy-2-pyridyl)-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

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About This Item

Formula empirica (notazione di Hill):
C15H13N3O5S
Numero CAS:
77459-78-0
Peso molecolare:
347.35
Beilstein:
5142716
Numero MDL:
MFCD23136990
Codice UNSPSC:
41116107
ID PubChem:
329754054
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

100

Nome Commerciale

VETRANAL®

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

CN1C(C(=O)Nc2ccc(O)cn2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C15H13N3O5S/c1-18-13(15(21)17-12-7-6-9(19)8-16-12)14(20)10-4-2-3-5-11(10)24(18,22)23/h2-8,19-20H,1H3,(H,16,17,21)
CCKOORANQAQKKV-UHFFFAOYSA-N

Descrizione generale

5′-Hydroxypiroxicam (CAS:77459-78-0) belongs to the VETRANAL product line of high purity veterinary drug standards used for the determination of the active ingredients of the drug in processed food of animal origin.

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Note legali

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number
SZBF320XV
SZBE224XV
SZBD032XV

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V Ródenas et al.
The Analyst, 123(8), 1749-1752 (1999-03-11)
A first-derivative spectrophotometric method for the simultaneous determination of piroxicam (PX) and its major metabolite 5'-hydroxypiroxicam (OH PX) in human plasma is described. The method consists of direct extraction of the two drugs from the plasma samples with hydrochloric and
A Klopas et al.
Journal of pharmaceutical and biomedical analysis, 17(3), 515-524 (1998-07-10)
A zero-crossing first-derivative spectrophotometric method for the determination of piroxicam and its major metabolite 5-hydroxypiroxicam (5-HP) in human plasma is described. This technique permits the quantification of compounds with closely overlapping spectral bands without any separation step. The method consists
B A Mueller et al.
Pharmacotherapy, 12(2), 93-97 (1992-01-01)
We compared the endoscopic effects and pharmacokinetic profiles of an experimental buccal formulation of piroxicam to oral capsules in an attempt to determine whether nonsteroidal antiinflammatory drug-induced gastropathy is due to a local or systemic effect. Ten healthy subjects received
A Avgerinos et al.
Journal of chromatography. B, Biomedical applications, 673(1), 142-146 (1995-11-03)
A simple and rapid (extractionless) high-performance liquid chromatographic method with UV detection, at 330 nm, was developed for the simultaneous determination of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma and urine. Acidified plasma and alkali-treated urine samples are
A C Rudy et al.
British journal of clinical pharmacology, 37(1), 1-5 (1994-01-01)
1. Piroxicam pharmacokinetics were assessed in three groups of subjects: (1) young healthy volunteers, (2) healthy elderly subjects (mean +/- s.d. creatinine clearance 88 +/- 13 ml min-1), and (3) elderly patients with renal insufficiency (creatinine clearance 60 +/- 10
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