04725

3-Hydroxyglutaric acid

analytical standard

• Sinonimo/i: β-Hydroxyglutaric acid, 3-Hydroxypentanedioic acid
• Formula empirica (notazione di Hill): C₅H₈O₅
• Numero CAS: 638-18-6
• Peso molecolare: 148.11
• NACRES: NA.24
• PubChem Substance ID: 329747978
• UNSPSC Code: 12352106
• MDL number: MFCD06208235
• Beilstein/REAXYS Number: 1705476

Proprietà

• grade: analytical standard
• Quality Segment: 100
• assay: ≥95.0% (GC)
• shelf life: limited shelf life, expiry date on the label
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• InChI: 1S/C5H8O5/c6-3(1-4(7)8)2-5(9)10/h3,6H,1-2H2,(H,7,8)(H,9,10)
• InChI key: ZQHYXNSQOIDNTL-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

3-Hydroxyglutaric acid is a glutaric acid derivative which is the byproduct of glutaric acidemia type I. Glutaric aciduria type I (glutaryl-CoA dehydrogenase deficiency) is an inborn error of metabolism that usually manifests in infancy by an acute encephalopathic crisis and often results in permanent motor handicap. Studies indicate that 3-hydroxyglutaric acid can be used as biomarker for GCDH (glutaryl-CoA dehydrogenase) deficiency. It is believed that the excretion of 3-hydroxyglutaric acid is increased during ketosis, which occurs during glutaryl-CoA dehydrogenase deficiency. Studies on striatal cultures show that IGF-1 and FGF-2 (bFGF) reduces 3-hydroxyglutaric acid toxicity in striatal neurons.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3