PC154
Anti-Excitatory Amino Acid Transporter (GLT-1) Rabbit pAb
liquid, Calbiochem®
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| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 100 μL | Per conoscere la disponibilità, visualizza il carrello | CHF 547.00 |
Informazioni su questo articolo
biological source
rabbit
Quality Level
antibody form
diluted serum
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
rat
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
dilution
(Immunoblotting (1:1000)
Immunoprecipitation )
isotype
IgG
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
Rattus norvegicus ... Slc1A2(29482)
General description
Immunogen
Application
Other Notes
Nagao, S., et al. 1997. Neuroscience78, 929.
Rothstein, J.D., et al. 1995. Ann. Neurol.14, 5559.
Arriza, J.L., et al. 1994. J. Neurosci.14, 5559.
Rothstein, J.D., et al. 1993. Proc. Natl. Acad. Sci. USA90, 6591.
Kanai, Y., et al. 1992. Nature360, 467.
Pines, G., et al. 1992. Nature360, 464.
Rothstein, J.D., et al. 1992. N. Engl J. Med.326, 1464.
Storck T., et al. 1992. Proc. Natl. Acad. Sci. USA89, 10955.
Legal Information
Disclaimer
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Questo articolo | |||
|---|---|---|---|
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| antibody form diluted serum | antibody form diluted serum | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| species reactivity rat | species reactivity mouse | species reactivity human | species reactivity rat, human, mouse |
| storage temp. −20°C | storage temp. −70°C | storage temp. −20°C | storage temp. −20°C |
| clone polyclonal | clone polyclonal | clone polyclonal | clone polyclonal |
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Classe di stoccaggio
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificati d'analisi (COA)
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Contenuto correlato
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| PC154-100UL | 04055977209488 |