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Key Documents

MABN502

Sigma-Aldrich

Anti-SNAT1 Antibody, clone N104/37

clone N104/37, from mouse

Sinonimo/i:

Sodium-coupled neutral amino acid transporter 1, Amino acid transporter A1, rATA1, Glutamine transporter, N-system amino acid transporter 2, Solute carrier family 38 member 1, System A amino acid transporter 1, System A transporter 2, System N amino acid

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

N104/37, monoclonal

Reattività contro le specie

mouse, human, rat

tecniche

immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG1κ

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SLC38A1(81539)

Descrizione generale

Sodium-coupled neutral amino acid transporter 1 (SNAT) is also called, Amino acid transporter A1 (ATA1), Glutamine transporter (Glnt), N-system amino acid transporter 2, Solute carrier family 38 member 1 (SLC38A1), System A amino acid transporter 1 (SAT1), System A transporter 2 (SA2), and System N amino acid transporter 1. SNAT functions as a sodium-dependent amino acid transporter that may supply glutamatergic and GABAergic neurons with the glutamine required for the synthesis of the neurotransmitters glutamate and GABA. SNAT is specifically expressed in brain, with the highest levels in cerebellum and thalamus, in glutamatergic, GABAergic and dopaminergic neurons, ependymal cells lining the ventricle and is also detected in spinal cord, heart, colon and placenta.

Specificità

This antibody recognizes the N-terminus of SNAT1.

Immunogeno

Epitope: N-terminus
Recombinant protein corresponding to the N-terminus of rat SNAT1.

Applicazioni

Detect Sodium-coupled neutral amino acid transporter 1 using this mouse monoclonal antibody, Anti-SNAT1 Antibody, clone N104/37 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SNAT1 in rat midbrain and human thalamus tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling

Qualità

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SNAT1 in 10 µg of human brain tissue lysate.

Descrizione del bersaglio

~ 54 kDa observed

Stato fisico

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
Human brain tissue lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Shanthie Thamotharan et al.
PloS one, 12(5), e0176493-e0176493 (2017-05-04)
Placental insufficiency leading to intrauterine growth restriction (IUGR) demonstrates perturbed gene expression affecting placental angiogenesis and nutrient transfer from mother to fetus. To understand the post-transcriptional mechanisms underlying such placental gene expression changes, our objective was to identify key non-coding
Karen J Gibbins et al.
Biology of reproduction, 98(5), 695-704 (2018-01-20)
Hypertensive disease of pregnancy (HDP) with placental insufficiency is the most common cause of fetal growth restriction (FGR) in the developed world. Despite the known negative consequences of HDP both to the mother and fetus, little is known about the

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