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Merck
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MABN448

Sigma-Aldrich

Anti-ENC-1 Antibody, clone 1H8.1

clone 1H8.1, from mouse

Sinonimo/i:

Ectoderm-neural cortex protein 1, ENC-1, Kelch-like protein 37, Nuclear matrix protein NRP/B, p53-induced gene 10 protein

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100 μG
CHF 389.00

CHF 389.00


Spedizione prevista il30 aprile 2025


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Cambia visualizzazione
100 μG
CHF 389.00

About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

CHF 389.00


Spedizione prevista il30 aprile 2025


Richiedi un ordine bulk

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

1H8.1, monoclonal

Reattività contro le specie

human, rat

tecniche

immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG2aκ

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ENC1(8507)

Descrizione generale

Ectoderm-neural cortex protein 1 (ENC1) as its name suggests is a protein involved in the regulation and differentiation of neural crest cells and neuronal development, as well as a protein involved in neuronal process formation later on. It is also known as nuclear matrix protein NRP/B. It is an actin binding protein that appears important in the organization of the actin cytoskeleton during neural fate specification and nervous system development. Its role in neuronal process formation is via its binding of RB1 (p110RB) when it is hypophosophorylated. ENC1 is widely expressed during development in the fetal heart, lung, and kidney. In the adult ENC1 is more restricted to nervous tissues primarily. It is abundant in adult brain, hippocampus, amygdale and spinal cord. There is also expression found in the adult pancreas. Numerous neuronal cancer cell lines and primary brain tumors also express ENC1. Localization is nuclear for the most part but in some cancer cells cytoplasmic staining is also observed. Its role in tumors is as an oncogene as studies suggest that both amplification and alteration of ENC1 may lead to tumor development and growth. Moreover ENC1 plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation as well.

Immunogeno

GST-tagged recombinant protein corresponding to human ENC-1.

Applicazioni

Anti-ENC-1 Antibody, clone 1H8.1 is a highly specific mouse monoclonal antibody, that targets Ectoderm-neural cortex-1 & has been tested in western blotting & IHC.
Western Blotting Analysis: 1 µg/mL from a representative lot detected ENC-1 in 10 µg of rat hippocampus tissue.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected ENC-1 in human cerebellum and cerebral cortex tissue.

Qualità

Evaluated by Western Blotting in human hippocampus tissue.

Western Blotting Analysis: 1 µg/mL of this antibody detected ENC-1 in 10 µg of human hippocampus tissue.

Descrizione del bersaglio

~66 kDa observed

Linkage

Replaces: MABC685

Stato fisico

Format: Purified

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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