MABN1587

Anti-MATR3 Antibody, clone 3G1.1

clone 3G1.1, from mouse

• Sinonimo/i: Matrin-3
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 3G1.1, monoclonal
• Reattività contro le specie: mouse, human
• tecniche: immunohistochemistry: suitable (paraffin); western blot: suitable
• Isotipo: IgG2bκ
• N° accesso NCBI: NP_001181884
• N° accesso UniProt: P43243
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... MATR3(9782)

Descrizione

Descrizione generale

Matrin-3 (UniProt P43243) is encoded by the MATR3 (also known as ALS21, KIAA0723, VCPDM) gene (Gene ID 9782) in human. Matrin-3 is an inner nuclear matrix protein involved in multiple nuclear processes, including DNA double strand break response, DNA replication/repair, chromatin organization, and RNA stability and processing. Matrin-3 contains two RNA recognition motifs (a.a. 398-473/RRM1 and a.a. 496-571/RRM2) that mediate RNA-binding and a DNA-binding zinc finger motif (a.a. 801-832). Matrin-3 is known to interact with the RNA-binding protein TDP-43 and MATR3 gene mutations are linked to amyotrophic lateral sclerosis (ALS). Matrin-3 is also a known target of multiple alpha herpes viruses and is known to be utilized by HIV-1 as a Rev cofactor.

Specificità

Expected to react with both spliced isoforms of human MATR3 reported by UniProt (P43243).

Immunogeno

GST-tagged recombinant internal fragment from the N-terminal half of human martin-3.

Applicazioni

Immunohistochemistry Analysis: An 1:250 dilution from a representative lot detected MATR3 in human cerebellum, human small intestine, and mouse cerebral cortex tissue sections.

This Anti-MATR3 Antibody, clone 3G1.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of MATR3.

Qualità

Evaluated by Western Blotting in SHSY-5Y cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected MATR3 in 10 µg of SHSY-5Y cell lysate.

Descrizione del bersaglio

~110 kDa observed. 94.62 kDa (isoform 1) and 62.58 kDa (isoform 2) calculated. The detected band size is consistent with the reported apparent molecular weight (Nakayasu, H., and Berezney, R. (1991). Proc. Natl. Acad. Sci. U. S. A. 88(22):10312-10316).

Stato fisico

Format: Purified

Altre note

Concentration: Please refer to lot specific datasheet.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable