MABE369

Anti-Suv4–20h2 Antibody, clone 6B9

clone 6B9, from rat

• Sinonimo/i: Histone-lysine N-methyltransferase SUV420H2, Lysine N-methyltransferase 5C, Suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2, Suv4-20h2
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rat
• Livello qualitativo: 100
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: 6B9, monoclonal
• Reattività contro le specie: human
• tecniche: western blot: suitable
• Isotipo: IgG2bκ
• N° accesso NCBI: NP_116090
• N° accesso UniProt: Q86Y97
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SUV420H2(84787)

Descrizione

Descrizione generale

Suppressor of variegation 4-20 homolog 2 (Suv4-20h2), also known as Lysine N-methyltransferase 5C (KMT5C), is a Histone-lysine N-methyltransferase that specifically trimethylates Lys-20 of histone H4. Suv4-20h2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. In mammals, Histone H4 Lys-20 trimethylation (H4K20me3) is one of the most common chromatin modifications and it has been implicated in various biological processes, including heterochromatin formation, telomere function, imprinting, X inactivation, DNA damage repair and cancer progression.

Immunogeno

GST-tagged recombinant protein corresponding to human Suv4-20h2.

Applicazioni

Detect the Suv4–20h2 protein using this Anti-Suv4–20h2, clone 6B9 validated for use in WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

Qualità

Evaluated by Western Blot in H9 human embryonic stem cell lysate.

Western Blot Analysis: 4.0 µg/mL of this antibody detected Suv4-20h2 in 10 µg of H9 human embryonic stem cell lysate.

Descrizione del bersaglio

~53 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~11 kDa and ~15 kDa

Stato fisico

Format: Purified

Protein G Purified

Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
H9 human embryonic stem cell lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable