MABC573
Anti-Bcl-2 Antibody, clone 1D7.2
clone 1D7.2, from rat
Sinonimo/i:
Apoptosis regulator Bcl-2, Bcl-2
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rat
Livello qualitativo
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
1D7.2, monoclonal
Reattività contro le specie
mouse
tecniche
western blot: suitable
Isotipo
IgG2aκ
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
mouse ... Bcl2(12043)
Descrizione generale
Apoptosis regulator Bcl-2 (UniProt P10417; also known as B-cell leukemia/lymphoma 2) is encoded by the Bcl2 (also known as Bcl-2, AW986256, C430015F12Rik, D630044D05Rik, D830018M01Rik) gene (Gene ID 12043) in murine species. Bcl-2 is an anti-apoptotic and the founding member of the Bcl-2 family of proteins that paly either a pro- or anti-apoptotic role in cell death signaling. BCL-2 family members are related by regions of sequence and structural homology. The pro-survival members contain four BCL-2 homology regions (BH1–BH4), whereas the BH3-only members contain only the BH3 amphipathic helix, which mediates their interaction with the groove of multi-domain BCL-2 family members. Human BCL2 gene mutatons are well known causes of many cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer.
Specificità
Expected to react with both spliced isoforms of murine Bcl-2.
Immunogeno
Epitope: N-terminal half
GST-tagged recombinant protein corresponding to the N-terminal of mouse Bcl-2.
Applicazioni
Detect Bcl-2 using this rat Monoclonal Anti-Bcl-2 Antibody, clone 1D7.2, Cat. No. MABC573, validated for use in Western Blotting.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Qualità
Evaluated by Western Blotting in mouse myoblast C2C12 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Bcl-2 in 10 µg of mouse myoblast C2C12 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Bcl-2 in 10 µg of mouse myoblast C2C12 cell lysate.
Descrizione del bersaglio
~22 kDa observed (26.4 kDa/isoform 1 & 22.3 kDa/isoform 2, calculated).
Stato fisico
Format: Purified
Protein G Purified
Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Stoccaggio e stabilità
Stable for 1 year at 2-8°C from date of receipt.
Altre note
Concentration: Please refer to lot specific datasheet.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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