ABS552
Anti-p40 Antibody
from rabbit, purified by affinity chromatography
Sinonimo/i:
Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prezzi e disponibilità al momento non sono disponibili
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
100
300
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
human
Reattività contro le specie (prevista in base all’omologia)
mouse (based on 100% sequence homology)
tecniche
immunohistochemistry: suitable (paraffin)
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... TP63(8626)
Descrizione generale
p40, also known as Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor , KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, or p51, and encoded by the gene TP63/KET/P63/P73H/P73L/TP73L, is a member of the p53 protein family. p40 is a sequence specific DNA binding transcriptional activator or repressor depending upon the target gene and the isoform involved. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specificactivity. p40 is involved in Notch signaling and plays a role in p53/TP53 dependent apoptosis and epithelial morphogenesis. Moreover p40, developmentally, is required for proper limb formation. p40 is expressed widely, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. Mutations in p40 lead to a variety of dysplasias and malformations, including Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome), Ankyloblepharon-ectodermal defects cleft lip/palate disorder (AEC), Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3), Split-hand/foot malformation 4 (SHFM4), Limb-mammary syndrome (LMS), Ectodermal dysplasia, Rapp-Hodgkin type (EDRH), Non-syndromic orofacial cleft 8 (OFC8).
Specificità
Uniprot describes multiple isoforms for this protein and based on the immunogen this antibody should recognize isoforms 2,4,6,8,10 and 12.
Immunogeno
Epitope: Transcription activation domain
KLH-conjugated linear peptide corresponding to the transcription activation domain of human p40.
Applicazioni
Anti-p40 | ABS552 is an antibody against p40 for use in Western Blotting, Immunohistochemistry (Paraffin).
Research Category
Signaling
Signaling
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
Western Blotting Analysis: 2.0 µg/mL from a representative lot detected p40 in 10 µg of human liver and human skin tissue lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Isocitrate dehydrogenase in squamous carcinoma cells.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Isocitrate dehydrogenase in squamous carcinoma cells.
Qualità
Evaluated by Western Blotting in human heart tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected p40 in 10 µg of human heart tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected p40 in 10 µg of human heart tissue lysate.
Descrizione del bersaglio
~63/56/51/46 kDa observed. Uncharacterized band(s) may appear in some lysates.
Stato fisico
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Stoccaggio e stabilità
Stable for 1 year at 2-8°C from date of receipt.
Altre note
Concentration: Please refer to lot specific datasheet.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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