ABN1038

Anti-Fbxo7 Antibody

• Sinonimo/i: F-box only protein 7|Fbxo7
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 300
• Clone: polyclonal
• Reattività contro le specie: mouse, human
• tecniche: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable

Descrizione

Descrizione generale

F-box only protein 7 (UniProt Q9Y3I1) is encoded by the FBXO7 (Also known as FBX, FBX7, PKPS, FBX07, PARK15) gene in human (Gene ID 25793). The Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligase complexes rely on their F-box protein component for substrate recognition. In addition to Fbxs, to which Fbxo7 belongs, there exist two other classes of F-box proteins, Fbws and Fbls. Fbxo7 recruits substrate via its C-terminal proline rich domain and associates with the adapter protein Skp1 via its F-box domain. In addition to mediating SCF-dependent ubiquitination, Fbxo7 is also involved in SCF-independent activities. Fbxo7 is reported to participate in autophagic clearance of damaged mitochondria (mitophagy) in response to mitochondrial depolarisation through direct interaction with PINK1 (PARK6) and Parkin (PARK2), while Parkinson′s disease-associated Fbxo7 mutations affect Parkin mitochondrial translocation and Parkin-mediated mitophagy.

Immunogeno

KLH-conjugated linear peptide corresponding to the C-terminus of human Fbxo7.

Applicazioni

Anti-Fbxo7 Antibody is an antibody against Fbxo7 for use in Western Blotting, Immunohistochemistry, Immunocytochemistry.

Immunohistochemistry Analysis: A 1:400 dilution from a representative lot detected Fbxo7 in human tonsil tissue.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Fbxo7 using U2OS cells transfected with constructs expres

Qualità

Evaluated by Western Blotting in Jurkat cell lysate.

Western Blotting Analysis: 1.0 ug/mL of this antibody detected Fbxo7 in 10 ug of Jurkat cell lysate.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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