AB5512
Anti-Homocysteine Antibody
serum, Chemicon®
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Origine biologica
rabbit
Forma dell’anticorpo
serum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
rat
Produttore/marchio commerciale
Chemicon®
tecniche
ELISA: suitable
Condizioni di spedizione
dry ice
modifica post-traduzionali bersaglio
unmodified
Descrizione generale
Homocysteine a sulphur containing amino acid, is formed by the transmethylation of methionine, an essential amino acid. Homocysteine may be irreversibly metabolised to cystathionine by cystathionine synthetase. This reaction uses pyridoxal phosphate (Vitamin B6) as a co-enzyme (see figure). The enzyme cystathionine synthetase is deficient in homocysteinuria, a rare genetic disease associated with high blood levels of homocysteine and the development of premature atherosclerosis. This and the association of other rare enzyme deficiencies with homocysteinemia and premature atherosclerosis led McCully to formulate the homocysteine hypothesis of atherosclerosis (McCully KS, The homocysteine theory of atherosclerosis. Atherosclerosis. 1976; 20: 23-27)
Specificità
Homocysteine
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
Homocysteine-G-BSA 1
Cysteine-G-BSA 1/450
Homocysteic acid-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
The cross-reactivities were determined using an ELISA test by competition experiments with the following compounds:
Compound Cross-reactivity ratio
Homocysteine-G-BSA 1
Cysteine-G-BSA 1/450
Homocysteic acid-G-BSA 1/>100,000
Abbreviations:
(G) Glutaraldehyde
(BSA) Bovine Serum Albumin
Immunogeno
Homocysteine-Glutaraldehyde-BSA
Applicazioni
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurofilament & Neuron Metabolism
Neurodegenerative Diseases
Neurofilament & Neuron Metabolism
Neurodegenerative Diseases
Suggested working dilution: 1:1,000-1:5,000
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
This Anti-Homocysteine Antibody is validated for use in ELISA for the detection of Homocysteine.
Stato fisico
Rabbit antiserum. Liquid with 0.05% sodium azide.
Stoccaggio e stabilità
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Amany Tawfik et al.
Journal of clinical medicine, 8(1) (2019-01-24)
Diabetic retinopathy (DR) is the most common cause of blindness in people under the age of 65. Unfortunately, the current screening process for DR restricts the population that can be evaluated and the disease goes undetected until irreversible damage occurs.
Hieronim Jakubowski
Physiological reviews, 99(1), 555-604 (2018-11-15)
Epidemiological studies established that elevated homocysteine, an important intermediate in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including heart and brain diseases. Earlier studies show that patients with severe hyperhomocysteinemia, first identified in the 1960s
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