AB2201
Anti-mPER1 (residues 6-21) Antibody
serum, from rabbit
Sinonimo/i:
Circadian clock protein PERIOD 1, Circadian pacemaker protein Rigui, Period, drosophila, homolog of period 1, period (Drosophila) homolog 1, period homolog 1 (Drosophila)
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100 μL
CHF 714.00
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Cambia visualizzazione
100 μL
CHF 714.00
About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
serum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
human, mouse, rat
tecniche
western blot: suitable
N° accesso Genebanck
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
mouse ... Per1(18626)
Descrizione generale
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
Specificità
Cat. # AB2201 will recognize the N-terminus of mPER1.
May react with Drosophila, Arvicanthis niloticus and Mesocricetus auratus based on sequence homology. Reactivity with other species has not been tested.
Applicazioni
Detect mPER1 (residues 6-21) using this Anti-mPER1 (residues 6-21) Antibody validated for use in WB.
Immunohistichemistry:
Tested on whole brain (SCN; peak staining at CT/ZT12). Optimium working dilutions need to be determined by end used.
Tested on whole brain (SCN; peak staining at CT/ZT12). Optimium working dilutions need to be determined by end used.
Qualità
Routinely tested by western blot on human brain lysate
Descrizione del bersaglio
136 kDa
Note legali
GenBank is a registered trademark of United States Department of Health and Human Services
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
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Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids.
Yasuhiro Umemura et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(1) (2021-12-22)
In mammals, circadian clocks are strictly suppressed during early embryonic stages, as well as in pluripotent stem cells, by the lack of CLOCK/BMAL1-mediated circadian feedback loops. During ontogenesis, the innate circadian clocks emerge gradually at a late developmental stage, and
Wenhao Ge et al.
Journal of lipid research, 64(6), 100390-100390 (2023-05-21)
Several epidemiological studies suggest a correlation between eating time and obesity. Night eating syndrome characterized by a time-delayed eating pattern is positively associated with obesity in humans as well as in experimental animals. Here, we show that oil intake at
Nobuko Katoku-Kikyo et al.
PLoS biology, 21(12), e3002419-e3002419 (2023-12-04)
Circadian regulation of gene expression is prevalent and plays critical roles in cell differentiation. However, its roles in the reprogramming of differentiated cells remain largely unknown. Here, we found that one of the master circadian regulators PER1 promoted virus-mediated reprogramming
Tomoko Ikeno et al.
Journal of biological rhythms, 31(4), 352-364 (2016-04-15)
In mammals, the circadian system is composed of a principal circadian oscillator located in the suprachiasmatic nucleus (SCN) and a number of subordinate oscillators in extra-SCN brain regions and peripheral tissues/organs. However, how the time-keeping functions of this multiple oscillator
Floriana Mogavero et al.
The European journal of neuroscience, 55(6), 1492-1503 (2022-03-02)
Although aggression has been linked to disturbances of circadian rhythm, insight into the neural substrate of this association is currently lacking. The suprachiasmatic nucleus (SCN) of the hypothalamus, the master circadian clock, is regulated by clock genes and known to
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