AB16942

Anti-DR5 Antibody, CT

Chemicon^®, from rabbit

• Sinonimo/i: Anti-CD262, Anti-DR5, Anti-KILLER, Anti-KILLER/DR5, Anti-TRAIL-R2, Anti-TRAILR2, Anti-TRICK2, Anti-TRICK2A, Anti-TRICK2B, Anti-TRICKB, Anti-ZTNFR9
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• PM: calculated mol wt-47.88 kDa; observed mol wt ~55 kDa
• Reattività contro le specie: human
• Produttore/marchio commerciale: Chemicon^®
• tecniche: western blot: suitable
• N° accesso NCBI: NM_003842.3; NM_147187.1
• N° accesso UniProt: O14763
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TNFRSF10B(8795)

Descrizione

Specificità

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2 or KILLER by several groups independently (Pan et al. 1997; Sheridan et al. 1997; Walczak et al. 1997; MacFarlane et al. 1997; Screaton et al. 1997; Wu et al. 1997; Chaudhary et al. 1997). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Immunogeno

Epitope: C-terminus

Polyclonal antibody raised against a peptide corresponding to amino acids 388-407 of human DR5 precursor (Pan et al. 1997; Sheridan et al. 1997).

Applicazioni

Anti-DR5 Antibody, C-terminus detects level of DR5 & has been published & validated for use in WB.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Western blot: 1:250 to 1:500

Whole cell lysate from HeLa or K562 cells can be used as a positive control .

Optimal working dilutions must be determined by end user.

Stato fisico

Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

Format: Purified

Stoccaggio e stabilità

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

Altre note

Click here for more information on observed vs. calculated molecular weight.


Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable