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554325

Sigma-Aldrich

Resveratrol

≥98% (HPLC), solid, COX-1 inhibitor, Calbiochem®

Sinonimo/i:

Resveratrol, trans-3,4ʹ,5-Trihydroxystilbene

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25 MG
CHF 74.10

CHF 74.10

Spedizione prevista il29 maggio 2025

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CHF 74.10

About This Item

Formula empirica (notazione di Hill):
C14H12O3
Numero CAS:
501-36-0
Peso molecolare:
228.24
Numero MDL:
MFCD00133799
Codice UNSPSC:
12191503
NACRES:
NA.77

CHF 74.10

Spedizione prevista il29 maggio 2025

Nome del prodotto

Resveratrol, A phenolic product found in both grape skins and wines.

Livello qualitativo

100

Descrizione

Merck USA index - 14, 8158

Saggio

≥98% (HPLC)

Stato

solid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
protect from light

Colore

off-white

Solubilità

DMSO: 50 mg/mL

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

Stringa SMILE

Oc1cc(cc(c1)\C=C\c2ccc(cc2)O)O

InChI

1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
LUKBXSAWLPMMSZ-OWOJBTEDSA-N

Descrizione generale

A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.

Azioni biochim/fisiol

Cell permeable: no
ED50 = 15 µM against COX-1
Primary Target
COX-1
Product does not compete with ATP.
Reversible: no

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Howitz, K.T., et al. 2003. Nature425, 191.
Lin, H.Y., et al. 2002. J. Urol.168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun.262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol.27, 363.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319

Classi di pericolo

Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

>392.0 °F - closed cup - (External MSDS)

Punto d’infiammabilità (°C)

> 200.0 °C - closed cup - (External MSDS)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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