553509

Ras/Rac Transformation Blocker, SCH 51344

A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling.

• Sinonimo/i: Ras/Rac Transformation Blocker, SCH 51344, 6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
• Formula empirica (notazione di Hill): C₁₆H₂₀N₄O₃
• Numero CAS: 171927-40-5
• Peso molecolare: 316.36
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: light yellow
• Solubilità: DMSO: 20 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C16H20N4O3/c1-10-14-15(17-5-7-23-8-6-21)12-9-11(22-2)3-4-13(12)18-16(14)20-19-10/h3-4,9,21H,5-8H2,1-2H3,(H2,17,18,19,20); YWEGXZZAORIRQR-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a K_d of 49 nM and inhibit its catalytic activity (IC₅₀ for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
Ras/Rac

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Altre note

Huber, K. V. M., et al. 2014. Nature In press.
He, H., et al. 1998. Mol. Cell. Biol.18, 3829.
Walsh, A.B., et al. 1997. Oncogene15, 2553.
Chandra Kumar, C., et al. 1995. Cancer Res.55, 5106.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable