538916

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

A cell-permeable and orally available synthetic PGE2.

• Sinonimo/i: 16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem
• Formula empirica (notazione di Hill): C₂₂H₃₆O₅
• Numero CAS: 39746-25-3
• Peso molecolare: 380.52
• Numero MDL: MFCD00151141
• Codice UNSPSC: 12352200

Proprietà

• Saggio: ≥95% (HPLC)
• Forma fisica: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Solubilità: DMSO: 100 mg/mL; ethanol: 100 mg/mL; PBS, pH 7.2: 5 mg/mL
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −70°C
• InChI: 1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6+,13-12+/t16-,17?,19-,20+/m0/s1; QAOBBBBDJSWHMU-BKSAQPBESA-N

Descrizione

Descrizione generale

A cell-permeable and orally available synthetic PGE2.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

Attenzione

Toxicity: Flammable (J)

Stato fisico

Supplied as a solution in methylacetate (1 mg/100 µL)

Nota sulla preparazione

Gently blow away methylacetate under a stream of N2 and solubilize in either DMSO or EtOH purged with an inert gas.

Ricostituzione

Following reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Goessling, W., et al. 2009. Cell136, 1136.
Fitzgerald, J., et al. 2000. Endocrinology141, 291.
Coleman, R.A., et al. 1994. Pharmacol. Rev.46, 205.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H319,H336
• Consigli di prudenza: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Organi bersaglio: Central nervous system
• Rischi supp: EUH066
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 3.2 °F - closed cup
• Punto d’infiammabilità (°C): -16 °C - closed cup