5.34347

hCNT2 Inhibitor

• Sinonimo/i: hCNT2 Inhibitor, 8-(4-Phenylbenzylamino)adenosine, Human Concentrative Nucleoside Transporter 2 Inhibitor
• Formula empirica (notazione di Hill): C₂₃H₂₄N₆O₄
• Numero CAS: 880155-70-4
• Peso molecolare: 448.47
• Codice UNSPSC: 12352200

Proprietà

• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: pale yellow
• Solubilità: DMSO: 50 mg/mL
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

An aminoadenosine derivative that acts as a potent human concentrative nucleoside transporter 2 inhibitor. Dose-dependently blocks Na⁺-dependent inosine uptake in COS-7 cells transiently expressing hCNT2 with an IC₅₀ of 0.64 µM. The anti conformer is suggested to be more bioactive than syn.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Azioni biochim/fisiol

Primary Target
hCNT2

Reversible: yes

Target IC₅₀: 640 nM in COS-7 cells

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Tatani, K., et al. 2015. ACS Med. Chem. Lett.6, 244.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable