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480403

NFAT Activation Inhibitor III

Name: NFAT Activation Inhibitor III
Brand: MM

The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Sinonimo/i:

NFAT Activation Inhibitor III, Inhibitor of NFAT- Calcineurin Association-6, INCA-6, Inhibitor of NFAT-Calcineurin Association-6, INCA-6

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Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₂₀H₁₂O₂

Numero CAS:

3519-82-2

Peso molecolare:

284.31

MDL number:

MFCD00226933

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Proprietà

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 5 mg/mL (Use only fresh DMSO.), ethanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

O=C1C2=C(C3c4c(cccc4)C2c5c3cccc5)C(=O)C=C1

InChI

1S/C20H12O2/c21-15-9-10-16(22)20-18-12-6-2-1-5-11(12)17(19(15)20)13-7-3-4-8-14(13)18/h1-10,17-18H

InChI key

GCHPUOHXXCNSQL-UHFFFAOYSA-N

Descrizione

General description

A cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (K_d = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.

A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (K_d = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 µM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.

Biochem/physiol Actions

Cell permeable: yes

Kd = 800 nM for calcineurin-NFAT

Primary Target
Calcineurin-NFAT

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Roehrl, M.H.A., et al. 2004. Biochemistry43, 16067.
Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA101, 7554.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

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Questo articolo	566405	401478	R6267
Sigma-Aldrich 480403 NFAT Activation Inhibitor III	Sigma-Aldrich 566405 Smad3 Inhibitor, SIS3	Sigma-Aldrich 401478 IκB Kinase Inactive Control Peptide, Cell-Permeable	Sigma-Aldrich R6267 RANTES human
description The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.	description Smad3 Inhibitor, SIS3, CAS 1009104-85-1, is a cell-permeable, selective inhibitor of TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated signaling. Does not affect Smad2, MAPK, ERK, or PI3-K.	description An inactive control for IκB Kinase Inhibitor Peptide.	description ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
form solid	form solid	form solid	form lyophilized powder
assay ≥95% (HPLC)	assay ≥90% (HPLC)	assay ≥97% (HPLC)	assay ≥97% (SDS-PAGE)
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
solubility DMSO: 5 mg/mL (Use only fresh DMSO.), ethanol: 5 mg/mL	solubility ethanol: 5 mg/mL, DMSO: 15 mg/mL	solubility water: 1 mg/mL	solubility -

Classe di stoccaggio

11 - Combustible Solids

Che succede?

WGK 1

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

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