219457

Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem

• Sinonimo/i: Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem, 2-(3-Hydroxypropylamino)-6-( o-hydroxybenzylamino)-9-isopropylpurine
• Formula empirica (notazione di Hill): C₁₈H₂₄N₆O₂
• Numero CAS: 471270-60-7
• Peso molecolare: 356.42
• Codice UNSPSC: 12352200

Proprietà

• Saggio: ≥95% (HPLC)
• Livello qualitativo: 100
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: DMSO: 10 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

This product has been discontinued.

An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC₅₀ = 100 nM) and Cdk2 (IC₅₀ = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition.

An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC₅₀ = 100 nM) and Cdk2 (IC₅₀ = 80 nM). Also displays anti-proliferative and pro-apoptotic effects.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
CDK1, CDK2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM, 80 nM, against Cdk1 and Cdk2, respectively

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Vermeulen, K., et al. 2002. Leukemia16, 299.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10-13 - German Storage Class 10 to 13