203895

BTS

A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility.

• Sinonimo/i: BTS, N-Benzyl- p-toluenesulphonamide, N-Benzyl-p-toluenesulphonamide
• Formula empirica (notazione di Hill): C₁₄H₁₅NO₂S
• Numero CAS: 1576-37-0
• Peso molecolare: 261.34
• Numero MDL: MFCD00159328
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Descrizione: RTECS - XT5490000
• Saggio: ≥95% (HPLC)
• Stato: crystalline solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: DMSO: 200 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [S](=O)(=O)(NCc2ccccc2)c1ccc(cc1)C
• InChI: 1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3; WTHKAJZQYNKTCJ-UHFFFAOYSA-N

Descrizione

Descrizione generale

A potent inhibitor of Ca²⁺-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

An aryl sulphonamide that acts as a potent inhibitor of Ca²⁺-stimulated myosin S1 actin-stimulated ATPase activity (IC₅₀ = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC₅₀ = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC₅₀<2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Ca²⁺-stimulated myosin S1 ATPase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: ~5 µM against Ca2+-stimulated myosin S1 ATPase

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Cheung, A., et al. 2002. Nat. Cell Biol.4, 83.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable