14-347-M

CHK2 Protein, active, 10 µg

Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.

• Codice UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Livello qualitativo: 100
• Ricombinante: expressed in E. coli
• Nome Commerciale: Upstate^®
• Attività specifica: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• PM: M_w 89.6 kDa
• Purificato mediante: (glutathione-agarose and Ni²⁺/NTA-agarose)
• Reattività contro le specie: human
• Produttore/marchio commerciale: Upstate^®
• tecniche: activity assay: suitable (kinase)
• Numero d’accesso: (FUNCTION: SwissProt: O96017 # Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on ′Ser-216′, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at ′Thr-18′ and ′Ser-20′. ); NM_001005735.1
• N° accesso NCBI: NM_001005735.1; NM_007194.3; NM_145862.2
• N° accesso UniProt: O96017
• Informazioni sul gene: human ... CHEK2(11200)

Descrizione

Descrizione generale

Recombinant human CHK2, residues 5-543, containing N-terminal GST and Cterminal His6 tags

Azioni biochim/fisiol

Protein Target: CHK2

Target Sub-Family: CAMK

Confezionamento

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-347M when ordering the 250 µg size.

Qualità

routinely evaluated by phosphorylation of the CHKtide substrate peptide

Descrizione del bersaglio

CHK2

Stato fisico

glutathione-agarose and Ni²⁺/NTA-agarose

Stoccaggio e stabilità

1 year at -70°C

Altre note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H317
• Consigli di prudenza: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classi di pericolo: Skin Sens. 1
• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°C): Not applicable