07-1548

Anti-HDAC11 Antibody

from rabbit

• Sinonimo/i: histone deacetylase 11
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Reattività contro le specie: human, mouse
• tecniche: ELISA: suitable; immunohistochemistry: suitable; western blot: suitable
• N° accesso NCBI: NP_079103
• N° accesso UniProt: Q96DB2
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... HDAC11(79885) ; mouse ... Hdac11(232232)

Descrizione

Descrizione generale

HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Specificità

Not tested in other species.

This antibody recognizes HDAC11.

Immunogeno

Epitope: N-terminus

The immunogen was a KLH-conjugated synthetic peptide corresponding the N-terminal region of human HDAC11.

Applicazioni

ELISA:
This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000).

Immunohistochemistry:
This antibody has been shown by an outside laboratory to be suitable for histochemistry using formalin fixed, paraffin embedded human hepatocarcinoma tissue (1:50-1:100).

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Cell Cycle, DNA Replication & Repair

Use Anti-HDAC11 Antibody (Rabbit Polyclonal Antibody) validated in WB, ELISA, IHC to detect HDAC11 also known as histone deacetylase 11.

Qualità

Western Blot Analysis:
Detection of HDAC11 in 10 µg of Mouse Brain lysate by Western blot analysis.

Descrizione del bersaglio

~40 kDa

Stato fisico

Format: Purified

Protein G Chromatography

Purified rabbit polyclonal in buffer containing 0.09% NaN3.

Stoccaggio e stabilità

Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Risultati analitici

Control
Mouse Brain cell lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable