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Merck
Tutte le immagini(1)

Documenti fondamentali

06-807

Sigma-Aldrich

Anti-LAT Antibody

Upstate®, from rabbit

Sinonimo/i:

Anti-IMD52, Anti-pp36

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

mouse, human

Produttore/marchio commerciale

Upstate®

tecniche

immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... LAT(27040)
mouse ... Lat(16797)

Specificità

Recognizes both forms of LAT.

Immunogeno

GST-tagged fusion protein corresponding to residues 31-233 of human LAT

Applicazioni

Anti-LAT Antibody detects level of LAT & has been published & validated for use in IP & WB.
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology

Qualità

routinely evaluated by immunoblot on RIPA lysates from Jurkat cells

Descrizione del bersaglio

36/38 kDa

Stato fisico

Format: Purified
Protein A Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
Protein A purified

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Risultati analitici

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha.
Clark, JM; Annenkov, AE; Panesar, M; Isomaki, P; Chernajovsky, Y; Cope, AP
Proceedings of the National Academy of Sciences of the USA null
T Harder et al.
The Journal of cell biology, 151(2), 199-208 (2000-10-19)
Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexes. Moreover, cholesterol-sphingolipid raft membrane domains have been implicated to play a role in TCR signal transduction. Here, we studied the assembly of
B S Wilson et al.
The Journal of cell biology, 154(3), 645-658 (2001-08-08)
In mast cells, cross-linking the high-affinity IgE receptor (Fc(epsilon)RI) initiates the Lyn-mediated phosphorylation of receptor ITAMs, forming phospho-ITAM binding sites for Syk. Previous immunogold labeling of membrane sheets showed that resting Fc(epsilon)RI colocalize loosely with Lyn, whereas cross-linked Fc(epsilon)RI redistribute
Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.
Wange, R L, et al.
The Journal of Biological Chemistry, 270, 18730-18733 (1995)
Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis.
S I Gringhuis, A Leow, E A Papendrecht-Van Der Voort, P H Remans, F C Breedveld, C L Verweij
Journal of immunology (Baltimore, Md. : 1950) (1950)

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