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06-342

Anti-JAK3 Antibody

Name: Anti-JAK3 Antibody
Brand: MM
Price: 304 CHF

serum, Upstate^®

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Taglio della confezione	SKU	Disponibilità	Prezzo
150 μL		Per conoscere la disponibilità, visualizza il carrello	CHF 304.00

Informazioni su questo articolo

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

CHF 304.00

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Servizio Tecnico

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG

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General description

125 kDa

Immunogen

peptide corresponding to residues 934-952 (RDELCVAGAQLYACQDPAI) of murine JAK3. The immunizing peptide sequence shares 16/19 amino acids with rat JAK3, but contains an amino acid insertion, which may block cross-reactivity. The immunizing peptide shares 12/19 amino acids with human JAK3.

Application

Anti-JAK3 Antibody is an antibody against JAK3 for use in WB.

Biochem/physiol Actions

: Recognizes murine JAK3, Mr 125kDa and JAK3 degradation products, Mr 95-120kDa. The antiserum shows very poor immunoreactivity for human JAK3. No immunoreaction was noted with immuno-precipitated mouse JAK1 and JAK2

This antibody has been tested on several human cell lines including A431, Hela, Jurkat, and HEK293 cells. The antiserum shows very poor immunoreactivity for human JAK3

Physical form

antiserum containing 0.05% sodium azide

Preparation Note

2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

routinely evaluated by immunoblot on lysate from a mouse cytotoxic T lymphocyte cell line (CTLL)

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 1

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Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.

Tsujino, S; Di Santo, JP; Takaoka, A; McKernan, TL; Noguchi, S; Taya, C; Yonekawa et al.

Proceedings of the National Academy of Sciences of the USA null

IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain.

R L Palmer-Crocker et al.

The Journal of clinical investigation, 98(3), 604-609 (1996-08-01)

IL-4 and IL-13 each act on human endothelial cells (ECs) to induce expression of vascular cell adhesion molecule-1. On hematopoietic cells. IL-4 responses may be mediated either through a pathway involving gc, the common signaling subunit of the IL-2, IL-4

Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation

Yu, C. L. and Burakoff, S. J.

The Journal of Biological Chemistry, 272, 14017-14020 (1997)

Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules.

Chen, X H, et al.

The Journal of Biological Chemistry, 272, 6556-6560 (1997)

An interleukin (IL)-13 receptor lacking the cytoplasmic domain fails to transduce IL-13-induced signals and inhibits responses to IL-4.

P L Orchansky et al.

The Journal of biological chemistry, 272(36), 22940-22947 (1997-09-05)

Interleukin (IL)-13 is a pleiotropic immunoregulatory cytokine that shares many, although not all, of the biological activities of IL-4. The overlapping biological properties of IL-4 and IL-13 appear to be due to the existence of shared components of the receptors

Visualizza tutti i documenti correlati

Contenuto correlato

JAK/STAT Signaling Research Focus

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.

Numero articolo commerciale globale

SKU	GTIN
06-342	04053252274572

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