06-018

Anti-ROR2 Antibody, CT

from rabbit

• Sinonimo/i: Neurotrophic tyrosine kinase, receptor-related 2, neurotrophic tyrosine kinase receptor-related 2, receptor tyrosine kinase-like orphan receptor 2, tyrosine-protein kinase transmembrane receptor ROR2
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Reattività contro le specie: human
• tecniche: immunohistochemistry: suitable (paraffin)
• N° accesso NCBI: NP_004551.2
• N° accesso UniProt: Q01974
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... ROR2(4920)

Descrizione

Descrizione generale

Receptor tyrosine kinase-like orphan receptor 2, also known as ROR2, is a member of the Tyr protein kinase family and ROR subfamily of cell surface receptors. Located in the transmembrane, ROR2 is highly expressed during early embryonic development and is associated with chondrocyte formation, cartilage and growth plate maturity. Expression levels of ROR2 subside after 16 days and occur minimally in adults. ROR2 is post translationaly modified by ATM or ATR phosphorylation when DNA damage occurs. Mutations in ROR2 result in brachydactyly type B1 (BDB1), characterized by either hypoplasia or aplasia of the distal phalanges and nails. ROR2 is also associated with recessive Robinow syndrome (RRS), resulting in shortening of limbs, facial dysmorphia and spinal defects.

Specificità

This antibody recognizes the C-terminal region of ROR2.

Immunogeno

Epitope: C-terminus

KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of ROR2

Applicazioni

Anti-ROR2 Antibody, C-terminus detects level of ROR2 & has been published & validated for use in IH(P).

Research Category
Inflammation & Immunology

Research Sub Category
Immunological Signaling

Qualità

Evaluated by immunohistochemistry (paraffin) in human gastric mucosa.

Immunohistochemistry(paraffin): 1:50-1:200 dilution of this antibody detected ROR2 in human gastric mucosa.

Descrizione del bersaglio

~105 kDa

Stato fisico

Format: Purified

Protein G Purified

Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8ºC from date of receipt.

Risultati analitici

Control
Human gastric mucosa

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable