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Merck
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Documenti

05-764

Sigma-Aldrich

Anti-MLL/HRX Antibody, NT., clone N4.4

clone N4.4, Upstate®, from mouse

Sinonimo/i:

Anti-ALL-1, Anti-ALL1, Anti-CXXC7, Anti-HRX, Anti-HTRX, Anti-HTRX1, Anti-MLL, Anti-MLL1, Anti-MLL1A, Anti-TRX1, Anti-WDSTS

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

N4.4, monoclonal

Reattività contro le specie

mouse, human

Produttore/marchio commerciale

Upstate®

tecniche

immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG1

N° accesso NCBI

NM_005933

N° accesso UniProt

Q03164

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... KMT2A(4297)

Descrizione generale

The acute lymphoblastic leukaemia (ALL)-1 (also known as MLL, HRX, HTRX, and TRX1) gene on human chromosome 11q23 is the site of many locally clustered chromosomal alterations associated with several types of acute leukaemias, including deletions, partial duplications and translocations. Structurally variant proteins derived from the altered gene presumably cause the malignant transformation of early haemopoietic progenitor cells.

Specificità

Recognizes N-terminal proteolytic fragment of MLL (MLLN).

Immunogeno

MBP fusion protein corresponding to residues 161-356 of human mixed lineage leukemia, MLL

Applicazioni

Detect MLL/HRX with Anti-MLL/HRX Antibody, N-term., clone N4.4 (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.

Qualità

routinely evaluated by immunoblot on nuclear extract from K562 cells

Descrizione del bersaglio

300 kDa

Stato fisico

Format: Purified
Immunoaffinity Purified immunoglobulin in 0.014M phosphate buffer, pH 7.6, 0.175M NaCl, 0.07% sodium azide, and 30% glycerol.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Chi Wai So et al.
Molecular and cellular biology, 22(18), 6542-6552 (2002-08-23)
MLL-AFX is a fusion gene created by t(X;11) chromosomal translocations in a subset of acute leukemias of either myeloid or lymphoid derivation. It codes for a chimeric protein consisting of MLL fused to AFX, a forkhead transcription factor that normally
Clara Bueno et al.
Cell research, 22(6), 986-1002 (2012-01-04)
The MLL-AF4 fusion gene is a hallmark genomic aberration in high-risk acute lymphoblastic leukemia in infants. Although it is well established that MLL-AF4 arises prenatally during human development, its effects on hematopoietic development in utero remain unexplored. We have created
Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation.
Heuts, et al.
Cells, 12 (2023)
J Paggetti et al.
Oncogene, 29(36), 5019-5031 (2010-06-29)
MOZ and MLL, encoding a histone acetyltransferase (HAT) and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblastic leukemia. In MOZ (MOnocytic leukemia Zinc-finger protein)/CBP- or mixed lineage leukemia (MLL)-rearranged leukemias, abnormal levels
Matthew J Smith et al.
Nature communications, 8(1), 1099-1099 (2017-10-25)
Elucidation of activation mechanisms governing protein fusions is essential for therapeutic development. MLL undergoes rearrangement with numerous partners, including a recurrent translocation fusing the epigenetic regulator to a cytoplasmic RAS effector, AF6/afadin. We show here that AF6 employs a non-canonical
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