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M-007

Supelco

(±)-Methadone solution

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formula empirica (notazione di Hill):
C21H27NO
Numero CAS:
76-99-3
Peso molecolare:
309.45
Numero CE:
200-659-6
Numero MDL:
MFCD00056289
Codice UNSPSC:
41116107
ID PubChem:
329817685
NACRES:
NA.24

Grado

certified reference material

Livello qualitativo

300

Forma fisica

liquid

Confezionamento

ampule of 1 mL

Produttore/marchio commerciale

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

Concentrazione

1 mg/mL in methanol

tecniche

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

applicazioni

forensics and toxicology

Formato

single component solution

Temperatura di conservazione

−20°C

Stringa SMILE

CCC(C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)=O

InChI

1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3
USSIQXCVUWKGNF-UHFFFAOYSA-N

Informazioni sul gene

human ... OPRM1(4988)

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Descrizione generale

Methadone is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. The drug is sold under several trade names such as Symoron, Dolophine®, Amidone, Methadose®, Physeptone, or Heptadon. This Certified Spiking Solution® is suitable for LC/MS or GC/MS testing methods in pain prescription monitoring, forensic analysis or clinical toxicology.

Applicazioni


  • Neurobehavioral and Molecular Changes in a Rodent Model: This study leverages Imipramine hydrochloride in a rodent model to investigate ACTH-induced HPA axis dysfunction, focusing on its effects on neurobehavior and molecular signaling pathways. This research underscores the utility of Imipramine hydrochloride in studying stress-related neuropsychiatric disorders, enhancing understanding of its therapeutic mechanisms in clinical settings (Sallie et al., 2024).

  • Electrochemical DNA Biosensor Development: Imipramine hydrochloride is used in the development of novel electrochemical DNA biosensors, highlighting its role in enhancing the sensitivity and specificity of genetic analysis. This application is pivotal in biotechnological advancements for genomics and personalized medicine (Augustín et al., 2024).

  • Diabetic Peripheral Neuropathy: Prevention and Treatment: Research incorporating Imipramine hydrochloride focuses on its effectiveness in managing symptoms of diabetic peripheral neuropathy, providing insights into its analgesic properties and mechanisms of action in nerve pain management, which is crucial for developing better therapeutic strategies (Bragg et al., 2024).

  • Microvesicle Particles in Burn Injury: Utilizes Imipramine hydrochloride in a study investigating the role of microvesicle particles in mediating damage in burn injury cases, offering a new perspective on the systemic impacts of burn injuries and the potential interventions to mitigate these effects (Lohade et al., 2024).

  • Sustainable Biosensor for Tricyclic Antidepressants: Highlights the use of Imipramine hydrochloride in the development of sustainable beeswax modified cellulose paper for the detection of tricyclic antidepressants in biofluids. This innovative approach represents a significant step forward in environmental sustainability and drug monitoring technologies (González-Bermúdez et al., 2024).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Dolophine is a registered trademark of Roxane Laboratories, Inc.
Methadose is a registered trademark of Mallinckrodt Inc.

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Avvertenze

Danger

Indicazioni di pericolo

H225,H301 + H311 + H331,H370

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organi bersaglio

Eyes

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

49.5 °F - closed cup

Punto d’infiammabilità (°C)

9.7 °C - closed cup

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Maintenance medication for opiate addiction: the foundation of recovery.
Bart G.
Journal of Addictive Diseases, 31(3), 207-225 (2012)
Philippa Hawley et al.
Pain research & management, 18(2), 83-86 (2013-05-11)
Methadone is one of the most important medications used for the treatment of refractory pain in the palliative care setting, and is usually initially prescribed by one of a limited number of physicians who have acquired authorization for its use.
Advice on methadone and oral health: dental public health in action.
C M Jones et al.
Community dental health, 30(2), 68-70 (2013-07-31)
David Kao et al.
Annals of internal medicine, 158(10), 735-740 (2013-05-22)
Long-acting opioids are a leading cause of accidental death in the United States, and methadone is associated with greater mortality rates. Whether this increase is related to the proarrhythmic properties of methadone is unclear. To describe methadone-associated arrhythmia events reported
The lethal burden of drug overdose.
Lancet (London, England), 382(9895), 833-833 (2013-09-10)
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