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860667P

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4E,8Z-Sphingadiene

Avanti Research - A Croda Brand 860667P, powder

Sinonimo/i:

(2S,3R,4E,8Z)-2-aminooctadec-4,8-diene-1,3-diol

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1 MG
CHF 234.00

CHF 234.00


Spedizione prevista il19 aprile 2025


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Cambia visualizzazione
1 MG
CHF 234.00

About This Item

Formula empirica (notazione di Hill):
C18H35NO2
Numero CAS:
Peso molecolare:
297.48
Numero MDL:
Codice UNSPSC:
12352211
NACRES:
NA.25

CHF 234.00


Spedizione prevista il19 aprile 2025


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Stato

powder

Confezionamento

pkg of 1 × 1 mg (860667P-1mg)

Produttore/marchio commerciale

Avanti Research - A Croda Brand 860667P

Tipo di lipide

sphingolipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

OC[C@@](N)([H])[C@]([H])(O)/C=C/CC/C=C\CCCCCCCCC

InChI

1S/C18H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h10-11,14-15,17-18,20-21H,2-9,12-13,16,19H2,1H3/b11-10-,15-14+/t17-,18+/m0/s1
RTQVJTLVVBJRJG-NZDSQIAKSA-N

Descrizione generale

4E,8Z-Sphingadiene is a unique sphingoid base containing C18 chain, with trans double bond at C-4 and cis double bond at C8.[1] It is widely present in plant tissues, but very minimal in mammals.[2]

Applicazioni

4E,8Z-Sphingadiene has been used as an standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) method for quantitation of chemopreventive sphingadienes in food products and biological samples.[3]

Azioni biochim/fisiol

Sphingadienes are growth-inhibitory sphingoid bases, which play a vital role in apoptosis and cell signaling.[4][5] Sphingadienes isolated from plants exhibit anti-inflammatory properties by inhibiting tumor necrosis factor α (TNF α) activity.[5]

Confezionamento

5 mL Amber Glass Screw Cap Vial (860667P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

No data available

Punto d’infiammabilità (°C)

No data available


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J H Suh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1061-1062, 292-299 (2017-08-05)
Colorectal cancer (CRC) is a leading cause of cancer mortality. Diet has a significant influence on colon cancer risk. Identifying chemopreventive agents, dietary constituents, practices and/or diet supplements that promote gut health and reduce the incidence of intestinal neoplasias and
An LC/MS/MS method for quantitation of chemopreventive sphingadienes in food products and biological samples
Suh JH, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1061, 292-299 (2017)
Structure of plasma sphingadienine
Renkonen O and Hirvisalo EL
Journal of Lipid Research, 10(6), 687-693 (1969)
O Renkonen et al.
Journal of lipid research, 10(6), 687-693 (1969-11-01)
The dienic long-chain base (sphingadienine) of human plasma sphingomyelins has been identified as d-erythro-1,3-dihydroxy-2-amino-4-trans-14-cis-octadecadiene. A similar sphingosine was also detected in plasma sphingomyelins of rat, rabbit, and cat. The key reaction in the structural studies was partial reduction of sphingadienine
Occurrence, structure elucidation, biosynthesis, functions and synthesis of sphingadienes
U Abeytunga T
Mini-Reviews in Organic Chemistry, 12(3), 282-292 (2015)

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