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850312P

Avanti

DOCPe

Avanti Research™ - A Croda Brand 850312P, powder

Sinonimo/i:

2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl ethyl phosphate

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About This Item

Formula empirica (notazione di Hill):
C45H86NO8P
Numero CAS:
1360461-58-0
Peso molecolare:
800.14
Numero MDL:
MFCD28143675
Codice UNSPSC:
51191904
NACRES:
NA.25
Prezzi e disponibilità al momento non sono disponibili

Saggio

>99% (TLC)

Stato

powder

Confezionamento

pkg of 1 × 200 mg (850312P-200mg)
pkg of 1 × 25 mg (850312P-25mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 850312P

Tipo di lipide

phospholipids
cardiolipins

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[H]C(C[N+](C)(CCOP([O-])(OCC)=O)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

InChI

1S/C45H86NO8P/c1-6-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-44(47)51-42-43(41-46(4,5)39-40-53-55(49,50)52-8-3)54-45(48)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-7-2/h21-24,43H,6-20,25-42H2,1-5H3/b23-21-,24-22-
WDTDXEZJIUAULM-SXAUZNKPSA-N

Descrizione generale

2-((2,3-bis(oleoyloxy)propyl)dimethylammonio)ethyl ethylphosphate (DOCPe) is a neutrally charged lipid.[1]
Inverse-phosphocholine lipids, a remix of a common phospholipid, contain headgroups with an inverted charge orientation relative to phosphocholine (PC) lipids. The iPC lipid headgroup has a quaternary amine adjacent to the bilayer interface and a phosphate that extends into the aqueous phase. Therefore iPC lipids afford a unique opportunity to investigate the biophysical and bioactivity-related ramifications of a charge inversion at the bilayer surface.

Applicazioni

DOCPe is suitable for liposomes preparation.[1]

Confezionamento

20 mL Clear Glass Screw Cap Vial (850312P-200mg)
5 mL Clear Glass Sealed Ampule (850312P-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

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Certificati d'analisi (COA)

Lot/Batch Number

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Charge and Coordination Directed Liposome Fusion onto SiO2 and TiO2 Nanoparticles
Wang X, et al.
Langmuir, 35(5), 1672-1681 (2018)
Yibo Liu et al.
Langmuir : the ACS journal of surfaces and colloids, 34(32), 9337-9348 (2018-03-13)
Phospholipids are a major component of the cell membrane. In most natural phospholipids, the phosphate acts as a bridge, connecting the other portion of the polar headgroup with the hydrophobic tails. Such bridging phosphate is chemically quite inert. Synthetic lipids
Emily K Perttu et al.
Journal of the American Chemical Society, 134(10), 4485-4488 (2012-03-01)
Zwitterionic inverse-phosphocholine (iPC) lipids contain headgroups with an inverted charge orientation relative to phosphocholine (PC) lipids. The iPC lipid headgroup has a quaternary amine adjacent to the bilayer interface and a phosphate that extends into the aqueous phase. Neutral iPC
Feng Wang et al.
Journal of the American Chemical Society, 137(36), 11736-11742 (2015-08-25)
Zwitterionic phosphocholine (PC) lipids are highly biocompatible, representing a major component of the cell membrane. A simple mixing of PC liposomes and silica (SiO2) surface results in liposome fusion with the surface and formation of supported lipid bilayers. However, the

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