800715P
Avanti
N-P Serine PA
Avanti Research™ - A Croda Brand 800715P, powder
Sinonimo/i:
N-palmitoyl-serine phosphoric acid (ammonium salt)
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1 MG
CHF 153.00
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1 MG
CHF 153.00
About This Item
Formula empirica (notazione di Hill):
C19H44N3O7P
Numero CAS:
Peso molecolare:
457.54
Numero MDL:
Codice UNSPSC:
12352211
NACRES:
NA.25
Saggio
>99% (TLC)
Stato
powder
Confezionamento
pkg of 1 × 1 mg (800715P-1mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand 800715P
Tipo di lipide
phosphoglycerides
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Descrizione generale
Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid is a competitive inhibitor of the LPA receptor in Xenopus oocytes.[1][2] However, in mammalian cells, N-palmitoyl-serine phosphoric acid may act as an agonist for the LPA receptor. [3][4] LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors.[1][2][3][4][5] LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation.[1] N-palmitoyl serine phosphoric acid may also play a role in signal transduction in mammalian cells by increasing intracellular calcium. [4][5]
N-palmitoyl serine phosphoric acid prevents human platelet aggregation, which is induced by 1-hexadecyl-2-lyso-sn-glycero-3-phosphate.[6]
Confezionamento
5 mL Amber Glass Screw Cap Vial (800715P-1mg)
Nota sulla preparazione
Product use: A range of 0.1-20 mM of N-palmitoyl serine phosphoric acid can be used for cell studies. Make a stock solution of 5 mM in DMSO and store at -20°C. Diluted N-palmitoyl serine phosphoric acid can be directly added to the study medium. [5]An et al. dissolved N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells.[4] In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.[2]
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Codice della classe di stoccaggio
11 - Combustible Solids
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids.
Bittman R, et al.
Journal of Lipid Research, 37(2), 391-398 (1996)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.
An, S
Molecular Pharmacology, 54, 881-888 (1998)
S B Hooks et al.
Molecular pharmacology, 53(2), 188-194 (1998-03-14)
Despite an intriguing cell biology and the suggestion of a role in pathophysiological responses, the mechanism of action of such lipid phosphoric acid mediators as lysophosphatidic acid (LPA) remains obscure, in part because of an underdeveloped medicinal chemistry. We report
Novel effect of N-palmitoyl-L-serine phosphoric acid on cytosolic Ca2+ levels in human osteoblasts
Jan, C.R
Pharmacology & Toxicology, 93, 71-76 (2003)
Chung-Ren Jan et al.
Pharmacology & toxicology, 93(2), 71-76 (2003-08-06)
The effect of N-palmitoyl-L-serine phosphoric acid (L-NASPA), which has been used as an inhibitor of lysophosphatidic acid receptors, on intracellular Ca2+ concentration ([Ca2+]i) in human osteosarcoma MG63 cells was measured by using fura-2. L-NASPA (0.1-10 microM) caused a rapid and
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