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Documenti

H5006

Sigma-Aldrich

Hesperidin methyl chalcone

Sinonimo/i:

(E)-1-[4-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-ß-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one

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About This Item

Formula empirica (notazione di Hill):
C29H36O15
Numero CAS:
24292-52-2
Peso molecolare:
624.59
Numero CE:
246-128-2
Numero MDL:
MFCD00010438
Codice UNSPSC:
12352100
ID PubChem:
24895666
NACRES:
NA.22

Attività ottica

[α]20/D −71°, c = 1 in ethanol

Livello qualitativo

100

Punto di fusione

120 °C (dec.) (lit.)

Stringa SMILE

COc1ccc(\C=C\C(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2OC)cc1O

InChI

1S/C29H36O15/c1-12-22(33)24(35)26(37)28(42-12)41-11-20-23(34)25(36)27(38)29(44-20)43-14-9-17(32)21(19(10-14)40-3)15(30)6-4-13-5-7-18(39-2)16(31)8-13/h4-10,12,20,22-29,31-38H,11H2,1-3H3/b6-4+/t12-,20+,22-,23+,24+,25-,26+,27+,28+,29+/m0/s1
FDHNLHLOJLLXDH-JIYHLSBYSA-N

Categorie correlate

Applicazioni

Involved in pharmacological studies of:
  • The effects on adhesion molecules in vascular endothelium
  • Thymidine monophosphate kinase inhibitors as antitubercular agents

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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USP

USP

1304377

Hesperidin

Cardamonin ≥98% (HPLC)

Sigma-Aldrich

C8249

Cardamonin

Neohesperidin dihydrochalcone ≥95% (HPLC)

Sigma-Aldrich

N8757

Neohesperidin dihydrochalcone

4-Chlorochalcone 97%

Sigma-Aldrich

558311

4-Chlorochalcone

Hesperidin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1794

Hesperidin

Phloridzin dihydrate from apple wood, ≥99% (HPLC)

Sigma-Aldrich

P3449

Phloridzin dihydrate

Naringin ≥90% (HPLC), from citrus fruit

Sigma-Aldrich

N1376

Naringin

trans-Chalcone 97%

Sigma-Aldrich

136123

trans-Chalcone

E Bouskela et al.
Journal of cardiovascular pharmacology, 22(2), 225-230 (1993-08-01)
The Ruscus extract and the flavonoid hesperidine methylchalcone (HMC) are used in treatment of venous insufficiency. In the present study, we used the hamster cheek pouch preparation and investigated the effects of these substances on increased microvascular permeability induced by
J L Chanal et al.
European journal of drug metabolism and pharmacokinetics, 6(3), 171-177 (1981-01-01)
Hesperidin methylchalcone resorption and excretion were studied in rats, using 14C-labelling. The level of radioactivity in the blood showed a peak 1-2 hours after oral administration of the labelled compound, at a dose of 10 mg/kg body weight. The blood
B I Roman et al.
Current medicinal chemistry, 20(2), 186-221 (2012-12-19)
One part of chemical space that is endowed with interesting biological properties is the area of the chalcones. With this review, we provide a comprehensive overview of the numerous in vivo animal studies on the antineoplastic potential of both natural
J J Guex et al.
International angiology : a journal of the International Union of Angiology, 29(6), 525-532 (2010-12-22)
The present study assessed the effect of Ruscus aculeatus, hesperidin methyl-chalcone and ascorbic acid (HMC-AA), in the treatment of chronic venous disorders (CVD) in Latin American patients. This study is an observational, single arm, multicentric and prospective trial. Patients suffering
F A Allaert et al.
International angiology : a journal of the International Union of Angiology, 30(3), 272-277 (2011-05-28)
The aim of this study was to compare the change in functional signs of venous insufficiency and venous refilling time measured by mercury strain-gauge plethysmography under the effects of the combination of Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid (Cyclo
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