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935166

Sigma-Aldrich

Hyaluronic acid

acid form, average Mw 25,000

Sinonimo/i:

HA

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About This Item

Formula condensata:
(C16H27NO11)n
Numero CAS:
Codice UNSPSC:
51202002
NACRES:
NA.21

Descrizione

acid form of hylauronic acid

Livello qualitativo

Forma fisica

powder or chunks (or Fibers)

PM

average Mw 25,000

Colore

white to faint yellow, Faint Brown

applicazioni

advanced drug delivery
(Tissue engineering)

Temperatura di conservazione

2-8°C

Descrizione generale

Hyaluronic acid (HA) is a a natural polymer found in many extracellular matrices (ECM). Its biocompatibility, biodegradability, and biomimetic chacteristics make it one of the most advantagous biopolymers for myriad of biomedical applications including drug delivery, tissue engineering, hydrogel development, cosmetics, regenerative medicine and 3D bioprinting.
Unlike other HA products which are typically available in a sodium salt form, HA acid form is soluble in organic solvents such as DMSO. This allows for a larger range of possible chemical modifications and functionalization. For instance, the carboxylic acid of the glucoronic acid can be modified or functionalized with hydrazine end groups.

Applicazioni

  • Tissue engineering including cartilage tissue engineering, bone tissue engineering, and other musculoskeletal tissues
  • Drug delivery and a carrier of small molecules, large molecules, and biomolecules
  • Biosensors, films and transdermal microneedles development
  • Medical device coatings, wound healing, and cosmetics

Caratteristiche e vantaggi

  • The same advantages of HA but in acid form
  • Soluble in organic solvents such as DMSO
  • Larger range of chemical modifications and functionalization possibilities

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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A mild and straightforward one-pot hyaluronic acid functionalization through termination of poly-(2-alkyl-2-oxazoline)
Madau M, et al.
Polymer, 230, 124059-124059 (2021)
Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory
Gupta R C, et al.
Frontiers in veterinary science, 25, 192-192 (2019)
Thiolated Hyaluronic Acid as Versatile Mucoadhesive Polymer: From the Chemistry Behind to Product Developments-What Are the Capabilities?
Griesser J, et al.
Polymers (Basel, Switzerland), 28, 243-243 (2018)

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