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Sigma-Aldrich

NanoFabTx™ NTA Lipid Mix

for synthesis of NTA-functionalized liposomes for small molecule delivery

Sinonimo/i:

Cholesterol, DGS-NTA(Ni), HSPC, PEG-DSPE

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About This Item

Codice UNSPSC:
12352211
NACRES:
NA.21

Livello qualitativo

100

Temperatura di conservazione

−20°C

Applicazioni

NanoFabTx™ NTA Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of NTA-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with NTA groups using extrusion and microfluidics are also included. The synthesized NTA-functionalized liposomes enable the conjugation of His-tagged antibodies or proteins to the liposomes surface for immunothereapy applications and multi-targeting or multi-type cargo delivery.

Caratteristiche e vantaggi

  • A ready-to-use nanoformulation lipid blend for the synthesis of NTA-functionalized liposomes
  • Step-by-step extrusion and microfluidics protocols for liposome synthesis developed and tested by our formulation scientists
  • Flexible synthesis methods to create uniform and reproducible liposomes
  • Protocols and lipid blend optimized to make liposomes around 100 nm diameter with low polydispersity
  • Lipid mix optimized for His-tagged protein or antibody conjugation and small molecule encapsulation
Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Note legali

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
TMAX is a trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Proceedings of the National Academy of Sciences (2019)
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The number and spacing of B-cell epitopes on antigens have a profound impact on the activation of B cells and elicitation of antibody responses, the quantitative aspects of which may be utilized for rational design of vaccines. Ni-chelating liposomes have

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