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730114

Sigma-Aldrich

2-Methacryloyloxyethyl phosphorylcholine

contains ≤100 ppm MEHQ as inhibitor, 97%

Sinonimo/i:

MPC

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5 G
CHF 173.00

CHF 173.00

Spedizione prevista il22 marzo 2025

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5 G
CHF 173.00

About This Item

Formula empirica (notazione di Hill):
C11H22NO6P
Numero CAS:
67881-98-5
Peso molecolare:
295.27
Numero MDL:
MFCD11112180
Codice UNSPSC:
12162002
ID PubChem:
329764541
NACRES:
NA.23

CHF 173.00

Spedizione prevista il22 marzo 2025

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Livello qualitativo

100

Saggio

97%

Stato

powder or crystals

contiene

≤100 ppm MEHQ as inhibitor

Punto di fusione

143-148 °C

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(=C)C(=O)OCCOP([O-])(=O)OCC[N+](C)(C)C

InChI

1S/C11H22NO6P/c1-10(2)11(13)16-8-9-18-19(14,15)17-7-6-12(3,4)5/h1,6-9H2,2-5H3
ZSZRUEAFVQITHH-UHFFFAOYSA-N

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Descrizione generale

2-Methacryloyloxyethyl phosphorylcholine (MPC) is a zwitterionic phosphorylcholine group-containing methacrylate monomer and is the most suitable monomer to mimic the phospholipid polar groups contained with cell membranes. It is also used in the preparations of a wide range of polymeric biomaterials because of its excellent resistance to nonspecific protein adsorption, biocompatibility, and low toxicity. It is also used to develop diverse molecular structures with adjustable properties using a range of polymerization methods, including living radical polymerization. Due to the reactivity of methacrylate, MPC-based materials have a wide range of applications in biomedical fields. Furthermore, MPC is also used as a monomer in the production of various polymeric materials for several applications such as medical devices, lithium-based batteries, contact lenses, drug delivery, wound dressings, and tissue engineering scaffolds.

Applicazioni

2-Methacryloyloxyethyl phosphorylcholine (MPC) can be used in the following applications:
  • Use as a monomer to produce fully zwitterionic polymer networks in a solvate ionic liquid for use as a gel electrolyte in lithium-based batteries.
  • Synthesis of polymer coatings for medical devices to prevent blood clotting and bacterial adhesion.
  • Preparation of hydrogels for use as contact lens materials and wound dressing.
  • Production of polymeric micelles and nanoparticles for drug delivery.
  • Use as a monomer to prepare polymer-modified antifouling silicone hydrogel contact lenses. The addition of MPC forms a cell membrane-like structure on the contact lens and helps to prevent cell and bacterial adhesion on the surface.

Caratteristiche e vantaggi

  • It has bioinert properties due to the presence of a zwitter ionic phosphorylcholine (PC) group in the side chain.
  • It can build various molecular architectures with tunable properties.
  • It has excellent resistance to cell adhesion, blood coagulation, and non-specific protein adsorption.

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08168

Timestrip Plus™ 8 °C

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317

Classi di pericolo

Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

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Certificati d'analisi (COA)

Lot/Batch Number
WXBF2318V
WXBF1766V
WXBD9937V
MKCN6263
MKCM4152

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Boxuan Ma et al.
Acta biomaterialia, 70, 186-196 (2018-02-17)
Intelligent drug delivery systems with prolonged circulation time, reduced drug leakage in blood, target site-triggered drug release and endosomal escape are attractive and ideal for malignant tumor therapy. Herein, doxorubicin (DOX)-conjugated smart polymeric micelles based on 4-carboxy benzaldehyde-grafted poly (L-lysine)-block-poly
N Nakabayashi et al.
Bio-medical materials and engineering, 14(4), 345-354 (2004-10-09)
Copolymers of 2-methacryloyloxyethyl phosphorylcholine (MPC) showed good hemocompatibility as hypothesized. The hypothesis was surfaces having phosphorylcholine groups by polymerization of MPC could accumulate phospholipids from blood stream and show good blood compatibility. We designed and prepared a methacylate having a
N Nakabayashi et al.
Biomaterials, 24(13), 2431-2435 (2003-04-18)
This review addresses the non-thrombogenic characteristics of copolymers based on 2-methacryloyloxyethyl phosphorylcholine (MPC), originally developed by Nakabayashi and colleagues. The hypothesis underlying these developments was that such materials would adsorb phospholipids from blood, yielding surfaces with good natural blood compatibility.
Yumiko Obayashi et al.
Frontiers in microbiology, 8, 1952-1952 (2017-10-27)
Microbial extracellular hydrolytic enzymes that degrade organic matter in aquatic ecosystems play key roles in the biogeochemical carbon cycle. To provide linkages between hydrolytic enzyme activities and genomic or metabolomic studies in aquatic environments, reliable measurements are required for many
Piers E Milner et al.
Acta biomaterialia, 65, 102-111 (2017-11-08)
Partial joint repair is a surgical procedure where an artificial material is used to replace localised chondral damage. These artificial bearing surfaces must articulate against cartilage, but current materials do not replicate both the biphasic and boundary lubrication mechanisms of
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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