European journal of biochemistry, 138(2), 319-325 (1984-01-16)
3-Oxo-3-phenylpropyne and 3-oxo-3-phenylpropene were synthesized as active-site-directed irreversible inhibitors of the bitter almond hydroxynitrile lyase (EC 4.1.2.10), an FAD-protein. The substrate and competitors (e.g. benzoate) decrease the rate of the inhibitor-mediated deactivation of the enzyme. By excess addition of either
Unsaturated lactones; researches on acetylenic compounds; a new route to growth-inhibitory alpha beta-ethylenic gamma- and delta-lactones.
L J HAYNES et al.
Journal of the Chemical Society, 954-957 (1946-10-01)
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