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702153

Sigma-Aldrich

Hydroxyapatite

nanoparticles, dispersion, 10 wt. % in H2O, <200 nm particle size (BET)

Sinonimo/i:

Calcium hydroxide phosphate, Calcium hydroxylapatite, Calcium hydroxyphosphate, Nano hydroxyapatatite, Pentacalcium hydroxide triphosphate

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25 ML
CHF 324.00

CHF 324.00


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Cambia visualizzazione
25 ML
CHF 324.00

About This Item

Formula condensata:
[Ca5(OH)(PO4)3]x
Numero CAS:
Peso molecolare:
502.31
Numero MDL:
Codice UNSPSC:
12352302
ID PubChem:
NACRES:
NA.23

CHF 324.00


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Stato

dispersion
nanoparticles

Livello qualitativo

contiene

≤0.025 wt. % dispersant (non-metal based)

Concentrazione

10 wt. % in H2O

Area superficiale

14.3 m2/g , typical

Dimensione particelle

<200 nm (BET)

pH

4-6

Densità

1.038 g/mL at 25 °C

Stringa SMILE

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10
XYJRXVWERLGGKC-UHFFFAOYSA-D

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Descrizione generale

Hydroxyapatite(HAP) is an osteoconductive bioceramic material which has uniqueability to form direct bonds with living tissues. It can be easily prepared byvarious techniques such as sol-gel, hydrothermal, multiple emulsion, biomimeticdeposition, and electrodeposition.

Applicazioni

Hydroxyapatite can be used as:
  • An implant material for bone substitute due to its chemical similarity to the inorganic component of bone and osteo inductive properties.
  • A vehicle for gene and drug delivery because of its encapsulation capacity and affinity to several drugs and proteins.
  • A pH responsive particulate emulsifier.

Caratteristiche e vantaggi

  • Biocompatible
  • Osteoconductive
  • Stable under physiological conditions
  • High mechanical strength

Note legali

Product of Engi-Mat Co.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Xi Chen et al.
The Journal of biological chemistry, 289(16), 11162-11174 (2014-03-13)
Calcium phosphate precipitates (CPPs) form complexes with DNA, which enter cells via endocytosis. Under this condition CPPs induce autophagy via the canonic autophagy machinery. Here we showed that CPP-induced autophagy was also dependent on endocytosis as the process was significantly
Liam M Grover et al.
Biomaterials, 34(28), 6631-6637 (2013-06-12)
Pyrophosphate ions are both inhibitors of HA formation and substrates for phosphatase enzymes. Unlike polyphosphates their hydrolysis results simultaneously in the complete loss of mineral formation inhibition and a localised elevation in orthophosphate ion concentration. Despite recent advances in our
W Zhang et al.
Journal of dental research, 92(12), 1136-1141 (2013-10-08)
Stem cell-based bone tissue engineering has been recognized as a new strategy for maxillary sinus floor elevation. More rapid bone formation may enhance this technique when simultaneous dental implant placement is desired. Adipose tissue-derived stem cells (ADSCs) and bone marrow
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There is an immense clinical need for novel therapeutics for the treatment of angiogenesis-dependent calcified neoplasms such as osteosarcomas and bone metastases. We developed a new therapeutic strategy to target bone metastases and calcified neoplasms using combined polymer-bound angiogenesis inhibitors.

Articoli

Nanoparticles can be used for applications such as growing cells for tissue engineering, nanocomposites used in orthopedics, and miniaturized sensors for DNA, pathogens, and chemicals.

Questions

  1. What is the dispersant used?

    1 answer
    1. The dispersant used is based on polyphosphoric acid, and approximately 0.25 wt% of hydroxyapatite is used.

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