232726

8-Methoxypsoralen

99%

• Sinonimo/i: 8-MOP, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, Ammoidin, Methoxsalen, Xanthotoxin
• Formula empirica (notazione di Hill): C₁₂H₈O₄
• Numero CAS: 298-81-7
• Peso molecolare: 216.19
• Beilstein: 196453
• Numero CE: 206-066-9
• Numero MDL: MFCD00005009
• Codice UNSPSC: 12352100

Proprietà

• Saggio: 99%
• Punto di fusione: 148-150 °C (lit.)
• Stringa SMILE: COc1c2OC(=O)C=Cc2cc3ccoc13
• InChI: 1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3; QXKHYNVANLEOEG-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca²⁺].