ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
Sinonimi:
HGPPS, HGPS, RBIG1, RIG1
Specie:
Human ROBO3 (64221), Mouse Robo3 (19649), Rat Robo3 (315564), Horse ROBO3 (100072287), sheep ROBO3 (101117204), cow ROBO3 (100337359), Zebrafish robo3 (30770), dog ROBO3 (489307), Domestic Rabbit ROBO3 (100342258), domestic cat ROBO3 (101084731) ...Più
ID UniProtKB:
ID gene:
- Human(64221) Summary: This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq, Dec 2009]
- Mouse(19649) roundabout homolog 3 (Drosophila)
- Rat(315564) roundabout, axon guidance receptor, homolog 3 (Drosophila)
- Horse(100072287) roundabout, axon guidance receptor, homolog 3 (Drosophila)
- sheep(101117204) roundabout, axon guidance receptor, homolog 3 (Drosophila)
- cow(100337359) roundabout, axon guidance receptor, homolog 3 (Drosophila)
- Zebrafish(30770) roundabout homolog 3
- dog(489307) roundabout, axon guidance receptor, homolog 3 (Drosophila)
- Domestic Rabbit(100342258) roundabout, axon guidance receptor, homolog 3 (Drosophila)
- domestic cat(101084731) roundabout, axon guidance receptor, homolog 3 (Drosophila)
- chicken(100858578) roundabout, axon guidance receptor, homolog 3 (Drosophila)
- domestic guinea pig(100721535) roundabout, axon guidance receptor, homolog 3 (Drosophila)
- fruit fly(33314) CG5423 gene product from transcript CG5423-RB
- naked mole-rat(101723272) roundabout, axon guidance receptor, homolog 3 (Drosophila)
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Antibodies
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Applicazione
Anti-ROBO3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
Anti-ROBO3 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
canine, human
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ELISA
flow cytometry
flow cytometry
esiRNA
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