NCOA2
nuclear receptor coactivator 2
Sinonimi:
GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75
Specie:
Human NCOA2 (10499), Mouse Ncoa2 (17978), Rat Ncoa2 (83724), domestic cat NCOA2 (101094648), naked mole-rat Ncoa2 (101700727), cow NCOA2 (508162), dog NCOA2 (486989), Horse NCOA2 (100051656), Zebrafish ncoa2 (81884), chicken NCOA2 (420176) ...Più
ID UniProtKB:
ID gene:
- Human(10499) Summary: The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]
- Mouse(17978) nuclear receptor coactivator 2
- Rat(83724) nuclear receptor coactivator 2
- domestic cat(101094648) nuclear receptor coactivator 2
- naked mole-rat(101700727) nuclear receptor coactivator 2
- cow(508162) nuclear receptor coactivator 2
- dog(486989) nuclear receptor coactivator 2
- Horse(100051656) nuclear receptor coactivator 2
- Zebrafish(81884) nuclear receptor coactivator 2
- chicken(420176) nuclear receptor coactivator 2
- domestic guinea pig(100735429) nuclear receptor coactivator 2
- sheep(101104249) nuclear receptor coactivator 2
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-NCOA2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunofluorescence
Anti-NCOA2 antibody produced in rabbit, ,
Reattività con
human, mouse, rat
Applicazione
immunohistochemistry
western blot
western blot
Anti-NCoA-2 Antibody, clone 3Ti-3C11, ,
Reattività con
feline, horse, human, mouse
Applicazione
ChIP
ELISA
western blot
ELISA
western blot
esiRNA
N° Catalogo
Descrizione
Specie